{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:18Z","timestamp":1790172138329,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Pediatric meningiomas make up 2% of all pediatric central nervous system tumors and are distinct from adult meningiomas, often coinciding with neurofibromatosis\u20102 (NF2). However, there is limited useful outcome data regarding pediatric meningiomas treated with radiation therapy (RT).<\/jats:p>\n <\/jats:sec>\n \n Procedures<\/jats:title>\n We identified 18 pediatric patients with meningiomas treated at our institution between 2006 and 2024 with proton therapy (PT). All patients received a total dose of 50.4\u201359.4\u00a0Gy in 1.8\u00a0Gy\/fraction daily, based on tumor grade. Nine patients had WHO Grade I meningiomas and nine had WHO Grade II meningiomas. Sixteen of 18 patients had gross disease at the time of RT. The male\u2010to\u2010female ratio was 1:1. Seven of 18 patients had an NF2 diagnosis. Kaplan\u2013Meier statistical analysis was employed to estimate progression\u2010free survival (PFS), local recurrence, and overall survival (OS) rates. We assessed toxicity during on\u2010treatment visits and follow\u2010ups based on severity and need for intervention.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Median follow\u2010up was 8.5\u00a0years (range: 0.5\u201318\u00a0years). No patients were lost to follow\u2010up. At 10\u00a0years, local control was 87%, PFS was 75%, and OS was 94%. One patient died from a radiation\u2010associated second neoplasm, and one died from cerebral vasculopathy occurring in the high\u2010dose region. Other notable radiation\u2010related toxicities included hearing loss (\n n<\/jats:italic>\n = 1), cataract formation (\n n<\/jats:italic>\n = 1), and endocrinopathy (\n n<\/jats:italic>\n = 2). No patients had progressive vision loss.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study contributes to the limited data for children with meningioma requiring RT. Long\u2010Term disease control was encouraging and aligned with adult meningioma data. Despite the use of PT, serious radiation toxicity was observed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/1545-5017.70003","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:50:01Z","timestamp":1767775801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes Following Proton Radiation for Pediatric Meningiomas"],"prefix":"10.1002","volume":"73","author":[{"given":"Elizabeth","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-1873","authenticated-orcid":false,"given":"Daniel J.","family":"Indelicato","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Brisson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Klawinski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Nemours Children's Specialty Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Ranalli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Florida College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond B.","family":"Mailhot Vega","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-018-2756-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010010\u20100503\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70275-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-012-1759-z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-024-04917-7"},{"key":"e_1_2_10_7_1","unstructured":"National Comprehensive Cancer Network \u201cNCCN Clinical Practice Guidelines\u2014Central Nervous System Cancers. Version 1 \u201dNational Comprehensive Cancer Network June 3 2025 p.1\u2013226 https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/cns.pdf."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(21)01259-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31739"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00165"}],"container-title":["Pediatric Blood & Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:15:22Z","timestamp":1790169322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/1545-5017.70003"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70003","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"2025-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70003"}}