{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:01:33Z","timestamp":1790172093260,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases\u2014especially those with high\u2010risk histology\u2014remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi\u2010targeted tyrosine kinase inhibitor, might enhance treatment efficacy through antiangiogenic mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This report included six children with relapsed WT treated between 2015 and 2022 at Bambino Ges\u00f9 Children's Hospital, Rome. All patients had received prior multimodal therapy, including six chemotherapeutic agents. The VIPaz regimen (vincristine, irinotecan, pazopanib) was administered as second\u2010 or third\u2010line therapy in combination with surgery and\/or radiotherapy. Treatment response and toxicity were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five out of six patients (83%) responded to the treatment. Three (50%) achieved complete remission and remained disease\u2010free at 27, 74, and 76\u00a0months post\u2010treatment. VIPaz was generally well\u2010tolerated. No Grade &gt;3 toxicities were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>VIPaz in combination with surgery and\/or radiotherapy demonstrated an acceptable safety profile and durable responses in 50% of heavily pretreated patients with relapsed high\u2010risk WT. Although limited by small sample size and retrospective design, these findings support further prospective evaluation of pazopanib\u2010based regimens and biomarker\u2010driven approaches in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70020","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:54:01Z","timestamp":1767776041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1082-6810","authenticated-orcid":false,"given":"Maria Debora","family":"De Pasquale","sequence":"first","affiliation":[{"name":"Oncohematology, Hemopoietic Transplantation Cellular Therapies and Clinical Trials Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-4233","authenticated-orcid":false,"given":"Alessandro","family":"Crocoli","sequence":"additional","affiliation":[{"name":"Surgical Oncology Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0250-6043","authenticated-orcid":false,"given":"Giuseppe Maria","family":"Milano","sequence":"additional","affiliation":[{"name":"Oncohematology, Hemopoietic Transplantation Cellular Therapies and Clinical Trials Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi Di","family":"Paolo","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Diomedi","family":"Camassei","sequence":"additional","affiliation":[{"name":"Pathology Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-8639","authenticated-orcid":false,"given":"Ida","family":"Russo","sequence":"additional","affiliation":[{"name":"Oncohematology, Hemopoietic Transplantation Cellular Therapies and Clinical Trials Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Serra","sequence":"additional","affiliation":[{"name":"Oncohematology, Hemopoietic Transplantation Cellular Therapies and Clinical Trials Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome 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