{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:01:58Z","timestamp":1790172118153,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study examines iron overload and assesses the safety and efficacy of chelation therapy in patients with leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The medical records of 208 children with acute leukemia were retrospectively screened. The iron status at diagnosis, cumulative packed red blood cell (pRBC) volume, number of pRBC transfusions, and iron burden of the patients at the end of intravenous chemotherapy were compared between patients who were and were not given iron chelation treatment with deferasirox.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 193 patients with leukemia were enrolled in the study. The average age was 65.5 months, and 56% were male. The patients were grouped according to receiving chelation therapy. Forty\u2010four patients (22.8%) received iron chelation therapy. High\u2010risk patients needed significantly more chelation treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The number of pRBC transfusions, cumulative pRBC volumes, and ferritin values at the beginning of maintenance therapy were significantly higher in patients who received chelation treatment (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). The cut\u2010off values for the predictivity of serum ferritin, cumulative pRBC volume, and number of pRBC transfusions in chelation need were determined as 1952\u00a0mcg\/L, 145\u00a0mL\/kg, and 12 times, respectively (0.933, 95% confidence interval [CI]: [0.887\u20130.964],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; 0.942, 95% CI: [0.899\u20130.970],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; 0.903, 95% CI: [0.853\u20130.941],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, respectively). Deferasirox was effective and safe in reducing iron burden. Only mild\u2010to\u2010moderate adverse effects were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Iron overload can develop in pediatric patients with leukemia and is associated with number of pRBC transfusions and cumulative pRBC transfusional volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70031","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:51:25Z","timestamp":1767678685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transfusional Iron Overload in Children With Leukemia"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-7347","authenticated-orcid":false,"given":"Nihal","family":"Karada\u015f","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Ege University Faculty of Medicine Children's Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkam","family":"Dolap\u00e7i","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ege University Faculty of Medicine Children's Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayshe","family":"Gadashova","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ege University Faculty of Medicine Children's Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u015fim","family":"Aydinok","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ege University Faculty of Medicine Children's Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selen","family":"Bayraktaro\u011flu","sequence":"additional","affiliation":[{"name":"Radiology Department\u2010\u0130ZM\u0130R Ege University Faculty of Medicine  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-4678","authenticated-orcid":false,"given":"Deniz","family":"Yilmaz Karapinar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ege University Faculty of Medicine Children's Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102141.2001.03195"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21663"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.627662"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"392","article-title":"Iron Overload in Myeloblastic Syndromes: Pathophysiology, Consquences, Diagnosis, and Treatment","volume":"9","author":"Lyle L.","year":"2018","journal-title":"Journal of the Advanced Practitioner in Oncology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24046"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/ijh\u20102021\u2010005"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2367-1"},{"key":"e_1_2_11_9_1","volume-title":"Standards for the Care of Children and Adults With Thalassemia in the UK","author":"Yardumian 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https:\/\/www.novartis.com\/us\u2010en\/sites\/novartis_us\/files\/jadenu.pdf."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40691-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31220"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2013.07.002"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020367"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0292"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001849"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.05.002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.11.017"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2019000036"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.07.070187.002413"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24629"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.03.039"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07970.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13053"}],"container-title":["Pediatric 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