{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:06:11Z","timestamp":1779541571854,"version":"3.53.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Burkitt lymphoma (BL) is a highly aggressive and invasive non\u2010Hodgkin lymphoma derived from germinal center B cells and represents one of the most common childhood malignancies. Matrix metalloproteinases (MMPs) play a critical role in cancer progression by remodeling the extracellular matrix and modulating the tumor microenvironment. In advanced stages, MMPs facilitate tumor invasion and metastasis through the degradation of extracellular matrix components. This study aimed to investigate the association between MMP\u20102 and MMP\u20109 gene polymorphisms and the pathogenesis of childhood BL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted at the Pediatric Oncohematology Center of the University of Pernambuco between 2021 and 2023 and included patients of both sexes aged 1 to 18 years diagnosed with BL between 1993 and 2023. Genomic DNA was extracted from peripheral blood samples using the salting\u2010out method. Polymorphisms were identified by real\u2010time polymerase chain reaction (PCR) using the TaqMan system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 56 patients diagnosed with BL were analyzed; most were male, with a mean age of 7.1 years. The overall survival rate was 92.6%. A protective effect of the mutant TT genotype was observed compared to the wild\u2010type CC genotype (OR = 0.0562; 95% CI: 0.0068\u20130.4644; p = 0.0016) for the MMP\u20102 polymorphism. Furthermore, individuals carrying the mutant G allele showed a positive association with BL compared to the wild\u2010type A allele (G vs. A: OR = 1.9920; 95% CI: 1.1812\u20133.3594; p = 0.0130).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings contribute to a better understanding of the genetic factors influencing BL susceptibility and support the need for further functional and large\u2010scale studies to elucidate the mechanistic role of MMP\u20102 and MMP\u20109 polymorphisms in BL pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70038","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:43:43Z","timestamp":1773639823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of\n                    <i>MMP\u20102<\/i>\n                    and\n                    <i>MMP\u20109<\/i>\n                    Polymorphisms and the Pathogenesis of Childhood Burkitt's Lymphoma"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0021-6342","authenticated-orcid":false,"given":"Elienay Ferreira","family":"da Silva","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology Oswaldo Cruz University Hospital University of Pernambuco  Recife Pernambuco Brazil"},{"name":"Graduate Program in Molecular and Cell Biology University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Marcos Chaves Fraz\u00e3o de Carvalho Ramos","family":"Neto","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology Oswaldo Cruz University Hospital University of Pernambuco  Recife Pernambuco 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