{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:07Z","timestamp":1790172127089,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007394","name":"Association Laurette Fugain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020320","name":"Institut pour la Recherche en Sant\u00e9 Publique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010076","name":"Conseil R\u00e9gional Provence-Alpes-C\u00f4te d'Azur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type\u20102\u2010diabetes, and metabolic dysfunction\u2010associated steatotic liver disease (MASLD). Lifestyle interventions, including a healthy diet and physical activity, are the cornerstone of the management of MetS. In long\u2010term childhood AL survivors with MetS, the benefits of classical lifestyle interventions remain poorly documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a one\u2010year dietary and behavioral intervention with monthly dietitian coaching in this specific population. We assessed clinical, biological metabolic parameters, noninvasive biomarkers of hepatic steatosis and fibrosis, and eating habits at baseline and after one year of coaching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 48 patients from the LEA cohort, diagnosed with MetS. The mean age was 32 years. At baseline, 62.2% of patients had hepatic steatosis and 15% had fibrosis F3\u2013F4 (VCTE &gt; 8\u00a0kPa). Daily energy intakes were already limited (average, 1611\u00a0Kcal\/day). After one year of lifestyle coaching, the body mass index (27.1\u00a0vs. 26.5\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.041) and the waist circumference (91.9\u00a0vs. 89.5\u00a0cm,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.027) had decreased. Daily intakes had significantly decreased (1213\u00a0Kcal\/day) with a healthier diet. Hepatic and metabolic parameters had not significantly improved in the study population. Liver steatosis was improved only in the subgroup of patients who lost weight and\/or waist circumference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Survivors of childhood AL have a high prevalence of MASLD at a young age. Classical lifestyle intervention appears incompletely efficient in improving metabolic and hepatic parameters in this specific population. New therapeutic approaches to reduce MetS and its complications in this unique population need to be studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70040","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T06:49:54Z","timestamp":1767595794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nutritional and Behavioral Intervention for Long\u2010Term Childhood Acute Leukemia Survivors With Metabolic Syndrome"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-4214","authenticated-orcid":false,"given":"Sandrine","family":"Visentin","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Immunology and Oncology, AP\u2010HM Timone Enfants Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"B\u00e9liard","sequence":"additional","affiliation":[{"name":"Nutrition Metabolic Diseases and Endocrinology Department AP\u2010HM La Conception Hospital  Marseille France"},{"name":"Aix Marseille University AP\u2010HM, INSERM, INRAE, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology IHOP, Hospices Civils De Lyon  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Caussy","sequence":"additional","affiliation":[{"name":"CarMen Laboratory INSERM, INRA, INSA Lyon, Lyon 1 Claude Bernard University  Lyon France"},{"name":"Department of Endocrinology Diabetes and Nutrition Lyon Hepatology Institute IHU EVEREST Lyon Sud Hospital Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Hamidou","sequence":"additional","affiliation":[{"name":"Research Unit UR 3279 and Department of Public Health Aix\u2010Marseille University and Timone Enfants Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Romano","sequence":"additional","affiliation":[{"name":"Research Unit UR 3279 and Department of Public Health Aix\u2010Marseille University and Timone Enfants Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Gacem","sequence":"additional","affiliation":[{"name":"Nutrition Metabolic Diseases and Endocrinology Department AP\u2010HM La Conception Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Petit","sequence":"additional","affiliation":[{"name":"Saint\u2010Antoine Research Center UMRS_938, \u201cHematopoietic and Leukemic Development,\u201d Sorbonne University  Paris France"},{"name":"Department of Pediatric Hematology and Oncology Armand Trousseau Hospital AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Saultier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Immunology and Oncology, AP\u2010HM Timone Enfants Hospital  Marseille France"},{"name":"Aix Marseille University AP\u2010HM, INSERM, INRAE, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Borentain","sequence":"additional","affiliation":[{"name":"Department of Gastro\u2010Enterology AP\u2010HM Timone Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Immunology and Oncology, AP\u2010HM Timone Enfants Hospital  Marseille France"},{"name":"Research Unit UR 3279 and Department of Public Health Aix\u2010Marseille University and Timone Enfants Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa060185"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117150"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70265-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510795"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn310"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02471-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.683"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12754"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-304899"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17716-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.167"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148908"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.176123"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70287-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0497"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.7511"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0116-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16091315"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-23-1601"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2024.107645"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu031"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.6.6.790"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw106"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29639"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30383-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328689"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.03.044"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.216077"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S13860"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112631"},{"key":"e_1_2_10_34_1","first-page":"374","volume-title":"A Randomized Nutrition Counseling Intervention in Pediatric Leukemia Patients Receiving Steroids Results in Reduced Caloric Intake","author":"Li R.","year":"2017"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181978fd4"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.977365"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24937"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02956-x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28670"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072137"},{"key":"e_1_2_10_41_1","first-page":"155","volume-title":"Effects of a Home\u2010Based Exercise Program on Metabolic Risk Factors and Fitness in Long\u2010Term Survivors of Childhood Acute Lymphoblastic Leukemia","author":"J\u00e4rvel\u00e4 L. S.","year":"2012"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1343104"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0482"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.147538"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31817e4ad9"},{"key":"e_1_2_10_47_1","first-page":"1461","volume-title":"Comparison of Childhood Cancer Survivors\u2019 Nutritional Intake With US Dietary Guidelines","author":"Zhang F. F.","year":"2015"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2013.770042"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.08.012"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0034"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.03.011"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023019804"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:15:07Z","timestamp":1790169307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,4]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/1545-5017.70040"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70040","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,4]]},"assertion":[{"value":"2025-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70040"}}