{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:10:59Z","timestamp":1790244659743,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The prognosis of diffuse intrinsic pontine glioma (DIPG) is dismal, with no established curative treatments. While DIPG frequently harbors diagnostically significant\n                    <jats:italic>H3F3A<\/jats:italic>\n                    mutations, it typically lacks molecularly targetable genetic abnormalities. Due to the tumor's location and the associated risks of morbidity and mortality from tissue sampling, standard care has traditionally relied on clinical symptoms and imaging for diagnosis and treatment decisions\u2014even at recurrence\u2014without biopsy. Herein, we present two cases of DIPG in which biopsy of disseminated lesions at recurrence revealed clinically significant genetic alterations, including high tumor mutational burden or a germline\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation. These findings underscore the potential clinical value of molecular genetic analysis from biopsied tissues, which may inform treatment decisions and guide patient management.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70043","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:50:03Z","timestamp":1766735403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance of Molecular Genetic Analysis in Diffuse Intrinsic Pontine Glioma: Two Case Reports"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-7417","authenticated-orcid":false,"given":"Itsuki","family":"Inamine","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Saitama Children's Medical Center  Saitama 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