{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:10:59Z","timestamp":1790244659790,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood & Cancer"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Myeloid\/NK cell precursor leukemia (MNKPL) is a rare, aggressive entity often misdiagnosed as acute myeloid leukemia (AML) or aggressive NK cell leukemia (ANKL) because of overlapping markers (CD7\n +<\/jats:sup>\n , CD13\/CD33\n +<\/jats:sup>\n , CD56\n +<\/jats:sup>\n , myeloperoxidase [MPO]\u2212). We report a patient initially diagnosed with ANKL; subsequent flow\u2010cytometric reevaluation (CD7\n +<\/jats:sup>\n , CD13\n +<\/jats:sup>\n , CD33\n +<\/jats:sup>\n , CD34\n +<\/jats:sup>\n , CD56\n +<\/jats:sup>\n , CD117\n +<\/jats:sup>\n , MPO\n \u2212<\/jats:sup>\n ) supported a diagnosis of MNKPL. RNA sequencing and nested PCR identified an in\u2010frame\n ZMYND11::MBTD1<\/jats:italic>\n fusion. A review of published\n ZMYND11::MBTD1<\/jats:italic>\n leukemias (\n n<\/jats:italic>\n = 5) found immunophenotypes highly consistent with MNKPL, suggesting prior misclassification. These findings support\n ZMYND11::MBTD1<\/jats:italic>\n as a recurrent lesion in MNKPL and a practical aid to diagnosis and treatment selection.\n <\/jats:p>","DOI":"10.1002\/1545-5017.70044","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T12:36:51Z","timestamp":1766839011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ZMYND11::MBTD1<\/i>\n Fusion in Myeloid\/NK Cell Precursor Leukemia: A Case Report With Literature Review and Diagnostic Implications"],"prefix":"10.1002","volume":"73","author":[{"given":"Hao","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou China"},{"name":"Soochow University and Children's Hospital of Soochow University Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1092-2984","authenticated-orcid":false,"given":"Xin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Suzhou Jsuniwell Medical Laboratory Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Suzhou Jsuniwell Medical Laboratory Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhuo","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8237-7930","authenticated-orcid":false,"given":"Peifang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou 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