{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:08:46Z","timestamp":1790244526275,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Children with congenital heart disease (CHD) have elevated neuroblastoma (NB) risk, potentially due to shared neural crest origins. We analyzed rare exonic de novo single\u2010nucleotide variants in 702 CHD and 454 NB trios from the Neuroblastoma Epidemiology in North America Study, Gabriella Miller Kids First Program, and a published cohort. Seven genes, including CHD risk genes\n                    <jats:italic>POGZ<\/jats:italic>\n                    and\n                    <jats:italic>LZTR1<\/jats:italic>\n                    (linked to Noonan syndrome and Schwannomatosis), showed nominal (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) enrichment in both cohorts.\n                    <jats:italic>CIC, IREB2, POGZ<\/jats:italic>\n                    , and\n                    <jats:italic>PCDHG<\/jats:italic>\n                    cluster are associated with neurodevelopmental disorders, supporting shared developmental mechanisms. Findings warrant investigation of pathways linking congenital anomalies and childhood cancer.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70055","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:03:57Z","timestamp":1766473437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Genetic Overlap Between Congenital Heart Disease and Neuroblastoma Risk"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-5967","authenticated-orcid":false,"given":"Ji Yun","family":"Tark","sequence":"first","affiliation":[{"name":"Section of Epidemiology and Population Sciences, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Renwick","sequence":"additional","affiliation":[{"name":"Department of Statistics Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UT MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Sabo","sequence":"additional","affiliation":[{"name":"Human Genome Sequencing Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Olshan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Plon","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad D.","family":"Huff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UT MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Lupo","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pediatrics School of Medicine Emory University  Atlanta Georgia USA"},{"name":"Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noae152"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804577"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1215"},{"issue":"5","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/cncr.22486","article-title":"Maternal and Perinatal Characteristics in Relation to Neuroblastoma","volume":"109","author":"Chow E. 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