{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:01:33Z","timestamp":1790172093047,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C1188\/A17297"],"award-info":[{"award-number":["C1188\/A17297"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from the IMPORT database for all newly diagnosed cases of Wilms tumour (WT) registered between November 2012 and December 2022. Kaplan\u2013Meier survival was estimated at one, three and five years. For children aged 0\u201314 years with unilateral WT, Cox proportional hazards models were used to examine patient\/tumour characteristics in relation to the excess hazard of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 620 patients, 570 had unilateral and 50 (8%) bilateral disease; 582 (94%) patients received pre\u2010operative chemotherapy and 38 (6%) immediate surgery. Median age was 41 months (IQR: 41\u201365). Median tumour volume at diagnosis was 595\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      (IQR: 348\u2013914) and 228\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      (IQR: 83\u2013535) after pre\u2010operative chemotherapy, with 123\/443 (28%) \u2265500\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      .\n                    <\/jats:p>\n                    <jats:p>Of 570 patients with unilateral WT, 419 (73.5%) had localised and 151 (26.5%) metastatic disease. Five\u2010year survival was highest for children aged 0\u20134 years (94.8%). Five\u2010year survival by Toronto stage (assessed at nephrectomy) was 97.0% (stage I\/yI), 93.8% (stage II\/yII), 85.2% (stage III\/yIII) and 88.9% (stage IV), and by histology 74.6% (high risk), 95.2% (intermediate risk) and 100% (low risk).<\/jats:p>\n                    <jats:p>\n                      In univariate analysis, histological risk group, age (&lt;\/\u2265 4 years), stage and tumour volume \u2265500\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      after pre\u2010operative chemotherapy were significantly associated with excess risk of death. In multivariate modelling, only high\u2010risk histology (HR 10.8, 95% CI: 4.0\u201329.1) retained significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Five\u2010year survival for children with WT in the United Kingdom and Ireland is generally above 90%, with high\u2010risk histology as the most important adverse prognostic factor. However, median tumour volume at diagnosis and after pre\u2010operative chemotherapy remains large.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70061","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:50:31Z","timestamp":1768553431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Survival for Children Diagnosed With Wilms Tumour (2012\u20132022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7264-7484","authenticated-orcid":false,"given":"Naomi","family":"Ssenyonga","sequence":"first","affiliation":[{"name":"Cancer Survival Group, Department of Non\u2010Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  London 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