{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:01:53Z","timestamp":1790172113089,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Recent studies show evidence of cognitive and psychosocial impairments and reduced quality of life (QoL) in adult survivors of childhood extracranial solid tumors and lymphomas, but limited research has addressed these issues in pediatric populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>The French RISK\u2010N prospective study (2014\u20132021) evaluated 278 survivors of extracranial solid tumors or lymphomas (47% female, mean age at diagnosis and assessment: 6.2 and 11.7\u00a0years). Patients with pre\u2010existing neurological conditions were excluded. Sociodemographic, disease\u2010related, and treatment data were collected. Cognitive performance was assessed using Wechsler Intelligence Scales for Children (WISC\u2010IV, WISC\u2010V). Psychosocial outcomes included parent and\/or patient\u2010reported executive functions (Behavior Rating Inventory of Executive Function), behavior (Conner's Parent Rating Scale), QoL (Pediatric Quality of Life Inventory), fatigue (Multidimensional Fatigue Scale), and depression (Children's Depression Inventory). Information on schooling and educational\/rehabilitative interventions was also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diagnoses included lymphoma (25%), nephroblastoma (19%), neuroblastoma (19%), osteosarcoma (7%), other sarcomas (18%), and other tumors (12%). Mean Full Scale Intellectual Quotient [\n                      <jats:italic>M<\/jats:italic>\n                      (SD) = 99.44(15.62)] was as expected in the general population [\n                      <jats:italic>M<\/jats:italic>\n                      (SD) = 100(15)], but the WISC\u2010IV Perceptual Reasoning Index was slightly lower [\n                      <jats:italic>M<\/jats:italic>\n                      (SD) = 95.4(15.0), &lt;1.5 SD 14%]. Parent\u2010 and self\u2010reports indicated greater executive dysfunction, inattention, fatigue, and reduced QoL. In multivariable regression models, poorer cognitive outcomes were associated with lower parental education and developmental\/learning delays before diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Objective cognitive deficits were uncommon among pediatric cancer survivors, contrasting with a relatively high level of subjective cognitive and psychosocial complaints, highlighting the need for systematic screening and tailored clinical interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70073","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:32:40Z","timestamp":1768037560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive and Psychosocial Outcome in Children and Adolescents Treated for Extracranial Malignant Solid Tumors and Lymphomas in the RISK\u2010N Study"],"prefix":"10.1002","volume":"73","author":[{"given":"Hugo","family":"C\u00e2mara\u2010Costa","sequence":"first","affiliation":[{"name":"Rehabilitation Department for Children with Acquired Brain Injury Paris Est Val De Marne Hospitals (Saint Maurice Site)  Saint Maurice France"},{"name":"Laboratoire D'imagerie Biom\u00e9dicale (LIB) Sorbonne Universit\u00e9, CNRS, INSERM  Paris France"},{"name":"Sorbonne Universit\u00e9 GRC 24 Handicap Moteur Cognitif et R\u00e9adaptation (HaMCRe) Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00e9","family":"Barrault","sequence":"additional","affiliation":[{"name":"Laboratoire D'imagerie Biom\u00e9dicale (LIB) Sorbonne Universit\u00e9, CNRS, INSERM  Paris France"},{"name":"Sorbonne Universit\u00e9 GRC 24 Handicap Moteur Cognitif et R\u00e9adaptation (HaMCRe) Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Department of Child and Adolescent Oncology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Longaud","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Oncology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Kieffer","sequence":"additional","affiliation":[{"name":"Rehabilitation Department for Children with Acquired Brain Injury Paris Est Val De Marne Hospitals (Saint Maurice Site)  Saint Maurice France"},{"name":"Department of Child and Adolescent Oncology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Grill","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Oncology Gustave Roussy  Villejuif 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