{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:10:58Z","timestamp":1790244658894,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sickle cell disease (SCD) is one of the most common inherited blood disorders worldwide, disproportionately affecting populations in sub\u2010Saharan Africa, India, the Middle East, and the Caribbean. Despite scientific advances in diagnostics, treatment, and emerging curative options, progress toward reducing the global burden of SCD remains hindered by fragmented efforts, inequities in access, and limited health system integration. Global partnerships are increasingly recognized as essential for fostering collaboration, aligning priorities, and ensuring that resources are deployed efficiently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This narrative review synthesizes evidence from peer\u2010reviewed literature, global health reports, and case studies of international and regional initiatives to examine the role of partnerships in advancing public health responses to SCD. Particular attention is given to screening, treatment access, advocacy, community engagement, and policy integration, with examples drawn from Africa, the Americas, India, and the Caribbean.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Global partnerships have demonstrated significant contributions to SCD control, including the expansion of newborn screening programs, improved access to hydroxyurea, enhanced blood transfusion safety, and advocacy\u2010driven policy reforms. Collaborative platforms such as the World Coalition on Sickle Cell Disease, the Consortium on Newborn Screening in Africa (CONSA), and regional networks in the Caribbean and India illustrate how coordinated efforts can reduce redundancy and improve outcomes. However, gaps remain in global coordination, data\u2010sharing, sustainable financing, and integration with broader maternal and child health programs. Practical strategies identified include the establishment of a Global Coordinating Council on SCD, development of a global data\u2010sharing framework, creation of regional hubs, and funding alignment mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Global partnerships are pivotal in moving toward a generation free from the burden of SCD. By fostering unity, reducing duplication, and ensuring equitable access to innovations, these collaborations provide a pathway for sustainable public health advancement. Achieving this vision requires a coordinated global framework that combines leadership, policy commitment, community engagement, and shared responsibility across all sectors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70079","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:26:03Z","timestamp":1767083163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Toward a Generation Free From the Burden of Sickle Cell Disease: The Role of Global Partnerships in Public Health Advancement"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-0161","authenticated-orcid":false,"given":"Emmanuel Ifeanyi","family":"Obeagu","sequence":"first","affiliation":[{"name":"Department of Biomedical and Laboratory Science Africa University  Mutare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"John","sequence":"additional","affiliation":[{"name":"Department of Allied Health Sciences The University of Chenab  Gujrat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(23)00118\u20107"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed9120292"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0348"},{"issue":"2","key":"e_1_2_15_5_1","first-page":"41","article-title":"Sickle Cell Disease: A Neglected Haemoglobinopathy Disorder With a Huge Global Burden","volume":"14","author":"Adebayo O. C.","year":"2023","journal-title":"Belgian Journal of Hematology"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13023"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/frhem.2024.1457158"},{"issue":"5","key":"e_1_2_15_8_1","first-page":"31","article-title":"Global Partnerships: Collaborative Efforts for International Sickle Cell Disease Education","volume":"11","author":"Obeagu E. I.","year":"2024","journal-title":"I"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00118-7"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00004-7"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1481441"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010016\u20101572\u20106"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24235"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272491"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103764"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010021\u201011794\u20106"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2023.08.002"},{"key":"e_1_2_15_18_1","unstructured":"World Health Organization \u201cSickle\u2010Cell Anaemia: Report by the Secretariat \u201dWHO 2005."},{"key":"e_1_2_15_19_1","volume-title":"Quality Education, Sustainable Communities, Human Rights: The Scientific Contribution of Italian UNESCO Chairs and Partners to SDGs 2030","author":"Josep\u2010e B.","year":"2019"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781003032724-7"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2024-017154"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007698"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.802355"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.805806"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/frhem.2023.1040720"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781003467748-5"},{"key":"e_1_2_15_27_1","volume-title":"What Only Heaven Hears: Citizens and the State in the Wake of HIV Scale\u2010Up","author":"Kenworthy N. J.","year":"2013"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000003082"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.20429\/jgpha.2020.080113"},{"key":"e_1_2_15_30_1","first-page":"55","volume-title":"Addressing Unmet Basic Needs for Children With Sickle Cell Disease in the United States: Clinic and Staff Perspectives","author":"Loo S.","year":"2021"},{"key":"e_1_2_15_31_1","volume-title":"Women's Experiences of Stillbirth and Other Reproductive Disruptions and Their Social Consequences in Southern Tanzania","author":"Haws R. A.","year":"2009"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2023000498"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_2064_20"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010907"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baz118"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00875-9"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2016.05.029"},{"key":"e_1_2_15_38_1","unstructured":"J.Owotomo \u201cThe Socioeconomic and Cultural Impact of Sickle Cell Disease in Nigeria \u201d2569 Walden Dissertations and Doctoral Studies 2016."},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-024-00738-3"},{"key":"e_1_2_15_40_1","volume-title":"Addressing Sickle Cell Disease: A Strategic Plan and Blueprint for Action","author":"Martinez R. M.","year":"2020"},{"key":"e_1_2_15_41_1","unstructured":"T. A.Royer \u201cImproving Clinician Care Practices of Patients with Sickle Cell Anemia: An Integrative Review \u201d 3065 Doctoral Dissertations and Projects 2021."},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-203142"},{"key":"e_1_2_15_43_1","unstructured":"T.B\u00fcnder \u201cThe Pharmaceutical Industry and Access to Health Products \u201dIFPMA 2022."},{"key":"e_1_2_15_44_1","unstructured":"P.Mlambo\u2010NgcukaandR.deSilva de Alwis \u201cRedefining Leadership in the Age of the SDGs: Accelerating and Scaling Up Delivery Through Innovation and Inclusion \u201d 2097 All Faculty Scholarship 2019."},{"issue":"7","key":"e_1_2_15_45_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0002066","article-title":"Mortality From Sickle Cell Disease in Brazil","volume":"5","author":"Blatyta P.","year":"2025","journal-title":"PLOS Global Public Health"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.02.005"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24711"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2024.07.010"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630269.2024.2344790"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000041062"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(25)00104-8"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/su14116601"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2017.08.010"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15030348"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025016053"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES-22-00137"},{"issue":"1","key":"e_1_2_15_57_1","first-page":"474","article-title":"The Current State of Sickle Cell Trait: Implications for Reproductive and Genetic Counseling","volume":"2018","author":"Pecker L. H.","year":"2014","journal-title":"Hematology (Amsterdam, Netherlands)"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16188"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-111521-102452"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1418382"},{"issue":"2","key":"e_1_2_15_61_1","first-page":"7","article-title":"Addressing Myths and Stigmas: Breaking Barriers in Adolescent Sickle Cell Disease Education","volume":"2","author":"Obeagu E.","year":"2024","journal-title":"Elite Journal of Health Science"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1611"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010907"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/20552076241290955"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/16549716.2022.2061239"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0004552"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S406196"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijns5010005"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2024000548"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2022.2063116"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:37:44Z","timestamp":1790242664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/1545-5017.70079"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70079","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70079"}}