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This study sought to explore the feasibility and acceptability of the\n                      <jats:italic>MedSupport<\/jats:italic>\n                      intervention strategies to support a future full\u2010scale randomized controlled trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, Participants, and Measures<\/jats:title>\n                    <jats:p>We recruited caregivers of pediatric patients (ages 1\u201318) with acute lymphoblastic leukemia (ALL) receiving oral home\u2010based chemotherapy at Roswell Park during April and May 2023. Multidisciplinary healthcare providers who were on the care teams of enrolled patients were invited to participate. Feasibility and acceptability among caregivers and healthcare providers were assessed using standardized self\u2010report measures and objective measures of intervention fidelity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We implemented a pilot study of the\n                      <jats:italic>MedSupport<\/jats:italic>\n                      intervention at Roswell Park, and successfully implemented all study procedures. Feasibility was demonstrated through: (i)\n                      <jats:italic>Demand<\/jats:italic>\n                      : When approached for participation, 100% of eligible caregivers (\n                      <jats:italic>N<\/jats:italic>\n                      = 6) and healthcare providers (\n                      <jats:italic>N<\/jats:italic>\n                      = 8) agreed to participate. (ii)\n                      <jats:italic>Practicality<\/jats:italic>\n                      : 100% of families completed the barriers screening questionnaire on the first prompt. All families endorsed adherence barriers (range: 3\u201314). (iii)\n                      <jats:italic>Acceptability<\/jats:italic>\n                      : Caregivers rated the intervention as acceptable, appropriate, and feasible (mean: 4.71\u20135.0). Healthcare providers rated the intervention as acceptable, appropriate, and feasible (mean: 4.41\u20134.47). Objective data on intervention fidelity were feasible to capture and demonstrated both caregiver and healthcare provider engagement with the intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>\n                      <jats:italic>MedSupport<\/jats:italic>\n                      is an innovative, low\u2010cost, and scalable intervention that warrants additional examination to understand efficacy in enhancing home\u2010based medication adherence in pediatric ALL.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70082","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:20:37Z","timestamp":1768036837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <i>MedSupport<\/i>\n                    Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing"],"prefix":"10.1002","volume":"73","author":[{"given":"Elizabeth G.","family":"Bouchard","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hital","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula C.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Center  Buffalo New York 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