{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:18:52Z","timestamp":1791389932287,"version":"4.3.3"},"reference-count":70,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis (PRISMA) guidelinesand was registered at the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023480732). Three databases (PubMed, MEDLINE (OVID), and CINAHL) were searched until March 2024. Studies with individuals aged 0\u201321 years with ALL during or after treatment were included. The Joanna Briggs Institute checklist was used to assess the bias risk. Of the 126 studies, 13 were included (eight cross\u2010sectional and five prospective). Eight studies used dual\u2010energy X\u2010ray absorptiometry, three used bioelectrical impedance analysis, two used air\u2010displacement plethysmography, and one applied the four\u2010compartment model. Fat mass (FM) increased early (T2\u2013T3 \u2248 +1standard deviation score [SDS]), and remained elevated at treatment end, and was above reference at follow\u2010up (T5 \u2248 +0.7 SDS). Fat\u2010free mass (FFM) declined during therapy (lowest at T4 \u2248 \u22120.7 SDS) with partial recovery by T5 (confidence interval crossing 0). Body mass index was elevated in the ALL groups versus controls. Heterogeneity was substantial, reflecting variation in age, assessment timing, and methodology. Despite methodological limitations, this review demonstrates persistent increases in FM and a reduction in FFM during and after treatment. Large, international studies using standardized body composition methodologies and clinically relevant cut\u2010offs are needed to define long\u2010term risks.<\/jats:p>","DOI":"10.1002\/1545-5017.70097","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:54:57Z","timestamp":1767678897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8733-3646","authenticated-orcid":false,"given":"Lina A.","family":"Zahed","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Faculty of Applied Medical Sciences King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Faculty of Population Health Sciences GOS Institute of Child Health, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-7146","authenticated-orcid":false,"given":"Raquel Revuelta","family":"Iniesta","sequence":"additional","affiliation":[{"name":"Children's Health and Exercise Research Centre (CHERC) Faculty of Health and Life Sciences Public Health and Sport Sciences Medical School, University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Fewtrell","sequence":"additional","affiliation":[{"name":"Faculty of Population Health Sciences GOS Institute of Child Health, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lanigan","sequence":"additional","affiliation":[{"name":"Faculty of Population Health Sciences GOS Institute of Child Health, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8700-9643","authenticated-orcid":false,"given":"Breeana","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Great Ormond Street Hospital, NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Great Ormond Street Hospital, NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00525-x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.53"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.247031"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2936"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28371"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16234119"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10091926"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031054"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09849-y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.195"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17936"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.9952"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24960"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17936"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.6962"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.018580"},{"issue":"1","key":"e_1_2_12_18_1","first-page":"56","article-title":"Body Composition Evaluation by Anthropometry and Bioelectrical Impedance Analysis in Childhood Acute Leukemia Survivors","volume":"37","author":"Aznar E. 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