{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:05:55Z","timestamp":1779541555311,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Children with cancer are at\u2010risk for infertility, yet most desire biological parenthood. Fertility preservation is available for pre\u2010 and postpubertal patients, with tissues typically banked for autologous use. Some survivors require third\u2010party reproduction (TPR) but do not complete the Food and Drug Administration (FDA)\u2010required donor eligibility steps when banking their reproductive materials. This article reviews medical and nonmedical factors associated with TPR, FDA regulatory requirements, risks of non\u2010compliance, and recommendations for facilitation in the pediatric oncology setting. Challenges, opportunities, and clinical decision trees for discussing TPR during pediatric fertility consultations are presented, emphasizing collaboration with adult reproductive clinics to support survivors\u2019 long\u2010term reproductive goals.<\/jats:p>","DOI":"10.1002\/1545-5017.70119","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:41:26Z","timestamp":1769262086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing Options for Future Third\u2010Party Reproduction Among Youth Newly Diagnosed With Cancer: Considerations for Pediatric Fertility Preservation Counseling"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-0417","authenticated-orcid":false,"given":"James L.","family":"Klosky","sequence":"first","affiliation":[{"name":"Department of Pediatrics &amp; Aflac Cancer and Blood Disorders Center Emory University School of Medicine Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-655X","authenticated-orcid":false,"given":"Brooke","family":"Cherven","sequence":"additional","affiliation":[{"name":"Department of Pediatrics &amp; Aflac Cancer and Blood Disorders Center Emory University School of Medicine Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-3176","authenticated-orcid":false,"given":"Vicky","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Amsterdam UMC Location University of Amsterdam &amp; Cancer Center Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena H.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology &amp; Reproductive Sciences &amp; Magee\u2014Womens Hospital, University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Rios","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology &amp; Reproductive Sciences &amp; Magee\u2014Womens Hospital, University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Irene","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Sciences and Moores Cancer Center, University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennia","family":"Michaeli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Smith","sequence":"additional","affiliation":[{"name":"Northwestern Medicine Group, Center for Fertility and Reproductive Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-1113","authenticated-orcid":false,"given":"Seth","family":"Rotz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cleveland Clinic Lerner College of Medicine of Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Bjornard","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(06)70724\u20100"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1687::AID-CNCR24>3.0.CO;2-M"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje\u201017\u20100054"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2020.0012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010014\u20102366\u20101"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426\u2010200606000\u201000006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100142(19990815)86:4<697::aid\u2010cncr20>3.0.co;2\u2010j"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2024.07.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.12703\/r\/10\u201055"},{"key":"e_1_2_7_11_1","unstructured":"Food and Drug Administration Eligibility Determination for Donors of Human Cells Tissues and Cellular and Tissue\u2010Based Products (HCT\/Ps): Guidance for Industry (U.S. Department of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research 2007) https:\/\/www.fda.gov\/regulatory\u2010information\/search\u2010fda\u2010guidance\u2010documents\/eligibility\u2010determination\u2010donors\u2010human\u2010cells\u2010tissues\u2010and\u2010cellular\u2010and\u2010tissue\u2010based\u2010products."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2024.06.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.05.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj243"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.6296"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010020\u201003193\u2010y"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx056"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28601"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.12.005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201009\u20100287"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.126643"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.10.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/482968"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3634"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4606"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.04.014"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10978"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.12.001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30551"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.315"},{"key":"e_1_2_7_33_1","unstructured":"Food and Drug Administration Recommendations to Reduce the Risk of Transmission of Disease Agents Associated With Sepsis by Human Cells Tissues and Cellular and Tissue\u2010Based Products (HCT\/Ps); 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