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Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (\n                    <jats:italic>PALB2)<\/jats:italic>\n                    in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed. Second, we report a pathogenic germline variant in\n                    <jats:italic>RAD50<\/jats:italic>\n                    in a patient with a rare prostate primary EwS and later concurrent relapsed EwS and therapy\u2010related acute myeloid leukemia (tAML) with two rare\n                    <jats:italic>KMT2A<\/jats:italic>\n                    translocations. Understanding rare pathogenic germline variants and the impact on cancer behavior, response to treatment and treatment\u2010associated toxicities is important for patients.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70122","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:40:53Z","timestamp":1768808453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathogenic Germline\n                    <i>PALB2<\/i>\n                    and\n                    <i>RAD50<\/i>\n                    Variants in Patients With Relapsed Ewing Sarcoma"],"prefix":"10.1002","volume":"73","author":[{"given":"Molly","family":"Mack","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Carolina","family":"Tufino","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Azrin","family":"Jamalruddin","sequence":"additional","affiliation":[{"name":"Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Department of Biochemistry and Biophysics Penn Center for Genome Integrity Basser Center for BRCA University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreya","family":"Dey","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology UPMC Magee\u2010Women's Hospital Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica D.","family":"Daley","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Meade","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Aarabi","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Maurer","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Cooper","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara A.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics Penn Center for Genome Integrity Basser Center for BRCA University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Bailey","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"},{"name":"Department of Pediatrics Mayo Clinic Children's, Mayo Clinic Comprehensive Cancer Center  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.206"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.04.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100003\u2010x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/2767\u20109764.CRC\u201021\u20100047"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27824"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00301"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201022\u20101535"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1942"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01907"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029841\u20100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00662"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-998-3_27"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1404-3243"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.1393"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523\u2010020\u201000174\u20109"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02151"}],"container-title":["Pediatric Blood &amp; 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