{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:05:56Z","timestamp":1779541556658,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>B\u2010cell lymphoblastic lymphoma (B\u2010LBL) represents a rare variety of non\u2010Hodgkin lymphoma, with limited research on its biology, progression, and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on the clinical characteristics of 256 patients aged \u226418 years who received treatment under the China Net Childhood Lymphoma (CNCL)\u2010NHL\u20102017\u2010lymphoblastic lymphoma regimen from April 2017 to March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 256 patients, the median age at diagnosis was 5.0 years, with a slight male predominance. Subcutaneous tissues, skin, and osteolytic bone were the most common sites of the disease. More than 90% of patients exhibited disseminated disease (Stage III or IV). Approximately 19.9% of the diagnosed patients exhibited central nervous system involvement. Adverse events were observed in 33 patients (12.9%), with disease progression or relapse occurring in 10.2% of cases, particularly linked to unfavorable outcomes in instances of early relapse or progression. Salvage chemotherapy combined with immunotherapies, followed by bridging hematopoietic stem cell transplantation, significantly improved the prognosis of relapse and disease progression in children. Overall, the follow\u2010up time was 37.6 (Q1\u2013Q3, 28.9\u201338.0) months, and 3\u2010year event\u2010free survival rate and overall survivals were 86.3%\u00a0\u00b1\u00a02.5% and 95.2%\u00a0\u00b1\u00a01.5%, respectively, with a treatment\u2010related mortality of 1.6%. Multivariate analysis showed that poor prednisone response and no complete remission on Day 33 of induction were risk factors for poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The CNCL\u2010NHL\u20102017\u2010lymphoblastic lymphoma regimen was effective in children with B\u2010LBL. The response to initial treatment is vital for improving prognosis in patients with B\u2010LBL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70161","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:56:28Z","timestamp":1769842588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Prognostic Risk Factors for Pediatric B\u2010Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1947-1805","authenticated-orcid":false,"given":"Zhijuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital)  Jinan 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Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital)  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital Affiliated to Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Lymphoma Beijing Gobroad Boren Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mincui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Hematology Hunan Children's Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hematology and Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan 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