{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:35:19Z","timestamp":1791858919682,"version":"4.3.4"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Severe transplant\u2010associated thrombotic microangiopathy (TA\u2010TMA), defined as multi\u2010organ dysfunction (MOD), is a life\u2010threatening complication of hematopoietic cell transplantation (HCT). We previously showed that D\u2010dimer is a novel prognostic marker; levels \u2265574\u00a0mg\/L at TA\u2010TMA diagnosis predicted the development of MOD. In this independent cohort of children with TA\u2010TMA (\n                    <jats:italic>n<\/jats:italic>\n                    = 45), D\u2010dimer levels \u2265574\u00a0mg\/L at diagnosis predicted MOD, with a sensitivity of 94.4 (95% confidence interval [CI]: 72.7\u201399.9) and a specificity of 63.6 (95% CI: 30.8\u201389.1). Ready availability and low cost make D\u2010dimer a promising marker for predicting patients at risk for developing severe disease and may inform treatment approaches.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70170","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T05:43:06Z","timestamp":1771825386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of D\u2010Dimer as a Prognostic Biomarker in Transplant\u2010Associated Thrombotic Microangiopathy in Children"],"prefix":"10.1002","volume":"73","author":[{"given":"Erin L.","family":"Frost","sequence":"first","affiliation":[{"name":"Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Ofori","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Kenney","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Spencer","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Obordo","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Pickett","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Pediatric Biostatistics Core Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Schoettler","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27186"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-564997"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001242"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.11.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.11.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019563"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.182"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T12:27:15Z","timestamp":1779539235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,22]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/1545-5017.70170"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70170","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,22]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70170"}}