{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:06:02Z","timestamp":1779541562558,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Indian Paediatric Haematology Oncology Group (INPHOG) multicentre study aimed to prospectively analyse the efficacy and safety of lenalidomide and dexamethasone (LENDEX) in children with refractory\/relapsed Langerhans cell histiocytosis (LCH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>The study was a prospective, multicentre study conducted through the INPHOG Histiocytosis Subcommittee. The Clinical Trials Registry of India registration was obtained, and the study was open to recruitment from June 2020 to June 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 15 children were included from seven centres in India, median age being 4 years (Range 3\u201313 years). Thirteen children were diagnosed to have multisystem disease at relapse with involvement of skin, bone and liver; and one child each with multifocal bone disease and single site bone lesion. One child with refractory lung disease had progression after two cycles of LENDEX and was taken off protocol. Four (26%) children achieved CR after six cycles of LENDEX; while eight (53%) children had PR at three and six cycles, with CR at the end of nine cycles of LENDEX. The combination was well tolerated, the most common adverse effects being mild anaemia and myalgia. There were no deaths within the cohort, with a median follow\u2010up of 24 months (Range 18\u201348 months). The overall response rate was 73%, with 26% responses at six cycles and 53% at nine cycles of LENDEX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LENDEX is well tolerated and effective in 73% children with relapsed\/refractory LCH. Future studies would include nine cycles of LENDEX followed by maintenance for 12 months with 6\u2010mercaptopurine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70217","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:46:10Z","timestamp":1773639970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Collaborative Study for Pulse Dexamethasone and Lenalidomide in Relapsed\/Refractory Langerhans Cell Histiocytosis (LENDEX\u2010LCH Study): INPHOG\u2010HIST\u201019\u201003 (CTRI\/2020\/07\/026937)"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-8214","authenticated-orcid":false,"given":"Ramya","family":"Uppuluri","sequence":"first","affiliation":[{"name":"Apollo Hospitals  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2570-7750","authenticated-orcid":false,"given":"Manas","family":"Kalra","sequence":"additional","affiliation":[{"name":"Sir Gangaram Hospital  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyendra","family":"Katewa","sequence":"additional","affiliation":[{"name":"Manipal Hospital  Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Kauvery Hospital  Trichy India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Post Graduate Institute of Child Health  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Dhamne","sequence":"additional","affiliation":[{"name":"Tata Memorial Centre and Homi Bhabha National University  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirisharani","family":"Siddaiahgari","sequence":"additional","affiliation":[{"name":"Rainbow Children's Hospital  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-4142","authenticated-orcid":false,"given":"Revathi","family":"Raj","sequence":"additional","affiliation":[{"name":"Apollo Hospitals  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.144527"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21504"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201003\u2010635151"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398\u2010199211000\u201000021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950210406"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096\u2010911x(199911)33:5<476::aid\u2010mpo7>3.0.co;2\u2010q"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201002\u2010556407"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.2.2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201009\u2010455774"},{"key":"e_1_2_10_13_1","unstructured":"LCH\u2010IV International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis. NCT02205762 https:\/\/clinicaltrials.gov\/study\/NCT02205762."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20578"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102230.1993.tb02262.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.31.15_suppl.e16555"},{"issue":"11","key":"e_1_2_10_18_1","first-page":"856","article-title":"\u00da\u010dinnost Lenalidomidu u Vz\u00e1cn\u00fdch Krevn\u00edch Chorob: U Histiocyt\u00f3zy Z Langerhansov\u00fdch Bun\u011bk, Multicentrick\u00e9 Castlemanovy Choroby, POEMS Syndromu, Erdheimovy\u2010Chesterovy Choroby a Angiomat\u00f3zy. Popis P\u0159\u00edpad\u016f a P\u0159ehled Literatury [The Effect of Lenalidomide on Rare Blood Disorders: Langerhans Cell Histiocytosis, Multicentric Castleman Disease, POEMS Syndrome, Erdheim\u2010Chester Disease and Angiomatosis]","volume":"58","author":"Adam Z.","year":"2012","journal-title":"Vnitrni Lekarstvi"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.631581"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70217","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T12:27:35Z","timestamp":1779539255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,15]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/1545-5017.70217"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70217","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,15]]},"assertion":[{"value":"2026-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70217"}}