{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:28:32Z","timestamp":1783171712958,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sickle cell disease (SCD) poses major reproductive health challenges for women. Evidence on pregnancy and maternal outcomes among women with SCD remains sparse from India. This study examined reproductive health, pregnancy\u2010related complications, and outcomes among women with SCD compared with age\u2010 and occupation\u2010matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A community\u2010based retrospective cross\u2010sectional study was conducted among women of reproductive age in five SCD\u2010endemic tribal areas of India. Data were collected through structured interviews covering pregnancy history, hydroxyurea use during the periconceptional\u2010to\u2010antenatal period, delivery, and postpartum outcomes. Of a cohort of 108 women with SCD, data of 37 ever\u2010married women with SCD with a history of conceptions and their matched controls were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women with SCD showed higher rates of anaemia (43% vs. 12.5%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), pain crises (42% vs. 11.5%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and blood transfusion during pregnancy (16% vs. 1%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). They also had more complications during delivery, including pain, fever, and emergency caesarean sections (10% vs. 3%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Postpartum complications such as pain, vaso\u2010occlusive crises, and ICU admissions were more frequent among SCD women. Birth preparedness was notably poorer. The proportion of live births to total conceptions was slightly lower among women with SCD (82% vs. 87%) due to a higher number of abortions and stillbirths. Only 10% of women with SCD used hydroxyurea during the periconceptional\u2010to\u2010antenatal period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women with SCD in tribal settings face considerable reproductive and maternal health risks. Integrating reproductive health and antenatal services into SCD care is essential to reduce maternal and neonatal morbidity in high\u2010burden, resource\u2010limited regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70229","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:39:02Z","timestamp":1773639542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reproductive Health and Pregnancy Outcomes Among Women With Sickle Cell Disease in Tribal Communities of India: A Community\u2010Based Retrospective Comparative Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-5513","authenticated-orcid":false,"given":"Yogita","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Socio\u2010Behavioural Health Systems and Implementation Research Indian Council of Medical Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-1718","authenticated-orcid":false,"given":"Deepa","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Anatomy JSS Medical College, JSS Academy of Higher Education and Research  Mysore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-6419","authenticated-orcid":false,"given":"Parikipandla","family":"Sridevi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Central Tribal University of Andhra Pradesh  Vizianagaram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0451-0879","authenticated-orcid":false,"given":"Shaily B.","family":"Surti","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Parul Institute of Medical Sciences and Research Parul University  Vadodara India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-6686","authenticated-orcid":false,"given":"Madhusmita","family":"Bal","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology Indian Council of Medical Research\u2013Regional Medical Research Centre  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8939-0495","authenticated-orcid":false,"given":"Jatin","family":"Sarmah","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bodoland University  Kokrajhar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8415-6701","authenticated-orcid":false,"given":"Manoranjan","family":"Ranjit","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology Indian Council of Medical Research\u2013Regional Medical Research Centre  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabindra K.","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology SCB Medical College  Cuttack India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-2222","authenticated-orcid":false,"given":"Bontha V.","family":"Babu","sequence":"additional","affiliation":[{"name":"Division of Socio\u2010Behavioural Health Systems and Implementation Research Indian Council of Medical Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510865"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00118-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(25)00260\u20101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2015.11.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1604179"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.5.1685"},{"key":"e_1_2_10_11_1","first-page":"405","article-title":"Maternal and Perinatal Outcomes in Pregnancies Complicated by Sickle Cell Diseases","volume":"32","author":"Nomura R. 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