{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:01:38Z","timestamp":1777942898932,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success. Prior work has shown that histone deacetylases (HDAC) inhibitors such as vorinostat show promise in reducing the incidence of graft\u2010versus\u2010host disease (GVHD) in allogenic transplant recipients and may mitigate some of the cognitive changes seen following transplant in adults. The current work presents a planned secondary analysis of a phase I\/II trial of vorinostat for GVHD prophylaxis (NCT03842696) to establish a cognitive and psychological safety profile for use of this emerging therapeutic in a sample of children, adolescents, and young adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two allogeneic transplant recipients (median age = 19) were evaluated with cognitive and health\u2010related quality\u2010of\u2010life (HRQL) measures prior to transplant and at 100 days and 180 days after transplant (\n                      <jats:italic>N<\/jats:italic>\n                      = 25 (cognitive) and 25 (HRQL) at final endpoint). Kolmogorov\u2013Smirnov tests and linear mixed effects modeling were used to compare cognitive performances and HRQL to normative levels and to examine changes over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Notable cognitive impairments prior to transplant remained relatively stable throughout the first 180 days post\u2010transplant, with no new neurocognitive safety signal over 180 days. Anxiety was apparent at baseline, but behavioral symptoms remained relatively well managed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results highlight cognitive impairments present prior to transplant and support prior findings in an adult population, suggesting that vorinostat does not result in additional cognitive or psychological deficits following transplant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70259","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:51:35Z","timestamp":1774335095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive Functioning in Vorinostat\u2010Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant"],"prefix":"10.1002","volume":"73","author":[{"given":"Kristen L.","family":"Votruba","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Rozwadowski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Braun","sequence":"additional","affiliation":[{"name":"School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-7936","authenticated-orcid":false,"given":"April","family":"Rahrig","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University Indiana  Bloomington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Peres","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Henry Ford Health Center  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Aflac Center for Cancer and Blood Disorders Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Fabrizio","sequence":"additional","affiliation":[{"name":"University of Colorado (Pediatrics) Boulder  Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie\u2010An","family":"Talano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Wisconsin  Milwaukee Wisconsin 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