{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:01:42Z","timestamp":1777942902854,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin\u2010based therapy, options for patients with multiply relapsed\/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high\u2010dose chemotherapy with autologous hematopoietic stem cell rescue (aHSCR). Three of the four patients had extensive metastases, four were cisplatin\u2010resistant, and three patients achieved CR. All patients experienced manageable, reversible toxicities with no significant delays in engraftment. Our findings suggest that including GemDMC as a component of sequential aHSCR is a promising salvage strategy for pediatric patients with relapsed\/refractory metastatic GCT.<\/jats:p>","DOI":"10.1002\/1545-5017.70266","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:16:26Z","timestamp":1774595786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gemcitabine, Docetaxel, Melphalan, Carboplatin as Part of Sequential Cycles of High\u2010Dose Chemotherapy With Autologous Hematopoietic Stem\u2010Cell Rescue for Multiply Relapsed\/Refractory Pediatric Germ Cell Tumors"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6569-8786","authenticated-orcid":false,"given":"Maria","family":"Frost","sequence":"first","affiliation":[{"name":"Department of Pediatrics The University of Texas MD Anderson Cancer Center  Houston Texas 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