{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:36:14Z","timestamp":1782261374513,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7252044"],"award-info":[{"award-number":["7252044"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2706100"],"award-info":[{"award-number":["2023YFC2706100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400172"],"award-info":[{"award-number":["82400172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study analyzed the genetic mutation spectrum, clinical characteristics, and therapeutic outcomes of pediatric B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) patients harboring\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was conducted on 32 pediatric B\u2010ALL patients with\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations admitted to Beijing Children's Hospital, Capital Medical University, from November 2019 to August 2025. Clinical data, genetic characteristics, treatment responses, and prognostic outcomes were collected and analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 32 patients, the male\u2010to\u2010female ratio was 1.46:1 (19 males and 13 females). The median age at onset was 7.0 (range: 1.5\u201314.0) years. Fusion genes were detected in 47% (15\/32) of patients, and abnormal karyotypes were present in 65% (20\/31) of patients. The complete remission (CR) rate after induction therapy was 100%. At the end of follow\u2010up, 29 patients remained disease\u2010free, while 3 patients experienced relapse. Outcomes for relapsed patients were poor despite various salvage therapies, including novel agents, CAR\u2010T therapy, and HSCT, and treatments were complicated by severe chemotherapy\u2010related adverse events. No deaths occurred during the study period. The 3\u2010year event\u2010free survival (EFS) for the entire cohort was 92% \u00b1 5%. Subgroup analyses based on mutation type and mutation site showed no significant differences in 3\u2010year EFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The incidence of\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations in pediatric B\u2010ALL is approximately 3%, and these cases are frequently accompanied by complex genetic features. Although the response to initial induction therapy is generally favorable, the prognosis becomes poor once relapse occurs, with limited efficacy observed from current salvage strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70276","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:23:06Z","timestamp":1774434186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Characteristics and Outcomes of Pediatric B\u2010Cell Acute Lymphoblastic Leukemia Harboring\n                    <i>TP53<\/i>\n                    Mutations: A Single\u2010Center Retrospective Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-5367","authenticated-orcid":false,"given":"Jinlei","family":"Yin","sequence":"first","affiliation":[{"name":"Laboratory of Hematologic Diseases, Hematology Center, Beijing Pediatric Research Institute, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"},{"name":"National Key Discipline of Pediatrics Capital Medical University  Beijing China"},{"name":"Key Laboratory of Major Diseases in Children Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"},{"name":"National Key Discipline of Pediatrics Capital Medical University  Beijing China"},{"name":"Key Laboratory of Major Diseases in Children Ministry of Education  Beijing 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Center for Children's Health Capital Medical University  Beijing China"},{"name":"National Key Discipline of Pediatrics Capital Medical University  Beijing China"},{"name":"Key Laboratory of Major Diseases in Children Ministry of Education  Beijing China"},{"name":"Hematology Center, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijing","family":"Qi","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"},{"name":"National Key Discipline of Pediatrics Capital Medical University  Beijing China"},{"name":"Key Laboratory of Major Diseases in Children Ministry of Education  Beijing China"},{"name":"Hematology Center, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"},{"name":"National Key Discipline of Pediatrics Capital Medical University  Beijing China"},{"name":"Key Laboratory of Major Diseases in Children Ministry of Education  Beijing China"},{"name":"Hematology Center, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5334-9706","authenticated-orcid":false,"given":"Zhigang","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Hematologic Diseases, Hematology Center, Beijing Pediatric Research Institute, Beijing Children's Hospital, National 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