{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:01:56Z","timestamp":1777942916277,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["GP1\u2010155872"],"award-info":[{"award-number":["GP1\u2010155872"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","award":["272PGX"],"award-info":[{"award-number":["272PGX"]}],"id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000233","name":"Genome British Columbia","doi-asserted-by":"publisher","award":["272PGX"],"award-info":[{"award-number":["272PGX"]}],"id":[{"id":"10.13039\/501100000233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003331","name":"Provincial Health Services Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000008","name":"Health Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>L\u2010asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L\u2010asparaginase, which compromises outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>\n                      Genome\u2010wide analyses were conducted to identify significant associations between single\u2010nucleotide polymorphisms and risk for L\u2010asparaginase\u2010induced pancreatitis in 1086 pediatric patients treated on acute lymphoblastic leukemia treatment protocols. Patients were randomly split 75\/25 into independent Discovery (\n                      <jats:italic>n<\/jats:italic>\n                      = 824) and Replication (\n                      <jats:italic>n<\/jats:italic>\n                      = 262) cohorts. Cases experienced Common Terminology Criteria for Adverse Events v5.0 Grades 3\u20134 acute pancreatitis reactions due to L\u2010asparaginase treatment. Controls received L\u2010asparaginase but did not develop acute pancreatitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant association was observed between the rs149210846 variant and L\u2010asparaginase\u2010induced pancreatitis (odds ratio [OR] = 8.9; 95% confidence interval [CI]: 3.6\u201322.3;\n                      <jats:italic>p<\/jats:italic>\n                      = 1.8 \u00d7 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      ) and was confirmed in the replication analysis (OR = 6.2; 95% CI: 1.1\u201335.0;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02). Carriers had 5.9\u2010fold (95% CI: 1.9\u201316.3;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) and 7.7\u2010fold (95% CI: 1.3\u201329.3;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01) increased risk of severe Grade 3 and Grade 4 acute pancreatitis reactions, respectively, relative to non\u2010carriers. Moreover, patients of Admixed\u2010American (OR = 8.8; 95% CI: 2.4\u201334.6;\n                      <jats:italic>p<\/jats:italic>\n                      = 1.45 \u00d7 10\n                      <jats:sup>\u22123<\/jats:sup>\n                      ) and Asian (OR = 10.0; 95% CI: 1.9\u201353.6;\n                      <jats:italic>p<\/jats:italic>\n                      = 8.06 \u00d7 10\n                      <jats:sup>\u22123<\/jats:sup>\n                      ) genetic ancestries were at significantly higher risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings will allow clinicians to proactively conduct stricter monitoring of patients at higher risk for L\u2010asparaginase\u2010induced pancreatitis and inform future development of protective agents that can be used concomitantly to mitigate their risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70284","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:15:48Z","timestamp":1774592148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Genetic Risk Factor Identified for L\u2010Asparaginase\u2010Induced Pancreatitis in Pediatric Patients With Cancer"],"prefix":"10.1002","volume":"73","author":[{"given":"Edward J.","family":"Raack","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-7083","authenticated-orcid":false,"given":"Wan\u2010Chun","family":"Chang","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-226X","authenticated-orcid":false,"given":"Miguel","family":"Cordova\u2010Delgado","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica N.","family":"Trueman","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Pharmaceutical Outcomes Programme BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika N.","family":"Scott","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catrina M.","family":"Loucks","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Anesthesiology, Pharmacology &amp; Therapeutics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrad R.","family":"Rassekh","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Division of Hematology, Oncology &amp; Bone Marrow Transplant, Department of Pediatrics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella S. S.","family":"Groeneweg","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Pharmaceutical Outcomes Programme BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Higginson","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Pharmaceutical Outcomes Programme BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Li","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Pharmaceutical Outcomes Programme BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fudan","family":"Miao","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Pharmaceutical Outcomes Programme BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Yau","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Pharmaceutical Outcomes Programme BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Johnston","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounira","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-7031","authenticated-orcid":false,"given":"Maja","family":"Krajinovic","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine  Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thai Hoa","family":"Tran","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine  Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Tewfik","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine  Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Bussi\u00e8res","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine  Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00efna\u2010Rafi","family":"Jean\u2010Baptiste","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine  Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Lebel","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine  Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Pecheux","sequence":"additional","affiliation":[{"name":"Stollery Children's Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bina","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Stollery Children's Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Guilcher","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gesche","family":"Riabowol","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert \u2019t","family":"Jong","sequence":"additional","affiliation":[{"name":"Winnipeg Health Sciences Centre  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Staub","sequence":"additional","affiliation":[{"name":"Winnipeg Health Sciences Centre  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Cuvelier","sequence":"additional","affiliation":[{"name":"Winnipeg Health Sciences Centre  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Felton","sequence":"additional","affiliation":[{"name":"Jim Pattison Children's Hospital  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Khalaj","sequence":"additional","affiliation":[{"name":"Jim Pattison Children's Hospital  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rieder","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awatif","family":"Abuzgaia","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamorah","family":"Lewis","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himal","family":"Ghimire","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Nathan","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Goralski","sequence":"additional","affiliation":[{"name":"IWK Health Centre  Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketan","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"IWK Health Centre  Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3138","authenticated-orcid":false,"given":"Zara","family":"Forbrigger","sequence":"additional","affiliation":[{"name":"IWK Health Centre  Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin J. D.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Faculty of Pharmaceutical Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-4054","authenticated-orcid":false,"given":"Bruce C.","family":"Carleton","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Pharmaceutical Outcomes Programme BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"62","article-title":"L\u2010Asparaginase in the Treatment of Patients With Acute Lymphoblastic Leukemia","volume":"7","author":"Egler R. A.","year":"2016","journal-title":"J"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.411"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401310"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74643-7_83"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V46.3.431.431"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"535","article-title":"L\u2010Asparaginase, Vincristine, and Prednisone for Induction of First Remission in Acute Lymphocytic Leukemia","volume":"37","author":"Ortega J. A.","year":"1977","journal-title":"Cancer Research"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"118","article-title":"Best Practices in Adolescent and Young Adult Patients With Acute Lymphoblastic Leukemia: A Focus on Asparaginase","volume":"4","author":"Boissel N.","year":"2015","journal-title":"J"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1101098"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006583"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05530-w"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28531"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.5812"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22076"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17959"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.203"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10214815"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.199356"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.763"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003060"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113000"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2023.2233412"},{"key":"e_1_2_9_24_1","unstructured":"\u201cCommon Terminology Criteria for Adverse Events (CTCAE) Version 5.0 \u201dU.S. Department of Health and Human Services National Institutes of Health National Cancer Institute 2017 https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/ctcae_v5_quick_reference_5x7.pdf."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142905.hg0119s68"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-901"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2307"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000529"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094052.109"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00187"},{"key":"e_1_2_9_32_1","unstructured":"R Core Team RCT \u201cR: A Language and Environment for Statistical Computing \u201dR Foundation for Statistical Computing 2021 https:\/\/www.R\u2010project.org\/."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1049"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad987"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1519-9"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.037"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022006965"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.07.080"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.047910"},{"issue":"33","key":"e_1_2_9_41_1","first-page":"E7776","article-title":"Inhibition of GCN2 Sensitizes ASNS\u2010Low Cancer Cells to Asparaginase by Disrupting the Amino Acid Response","volume":"115","author":"Nakamura A.","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00052.2016"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2217\/pme-2017-0022"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165987"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-023-01026-0"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn2110"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136397"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:10:31Z","timestamp":1777705831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/1545-5017.70284"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70284","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"2025-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70284"}}