{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:00:48Z","timestamp":1782896448667,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>Radiation therapy (RT) is part of standard\u2010of\u2010care therapy in high\u2010risk neuroblastoma (HR\u2010NBL) but can significantly affect nearby tissue. The objectives of this study were (1) to characterize changes in pancreas volume after RT and (2) to characterize changes in body composition, including body weight percentile, subcutaneous fat area, and total psoas muscle area (tPMA), after RT in children with abdominal HR\u2010NBL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included patients aged 0\u201317 years old with HR\u2010NBL cared for at a quaternary pediatric hospital (January 2012\u2013December 2022). Pre\u2010 to post\u2010RT differences in outcomes were compared using paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, then modeled using linear regression to adjust for covariates and additional variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty patients (median age 3 [IQR 2], 56% male) met the inclusion criteria. Median days from end of radiation to first post\u2010radiation imaging was 15.5 days (IQR 14). Pre\u2010 to post\u2010RT, mean pancreatic volume decreased significantly (from 16,731\u00a0mm\n                      <jats:sup>3<\/jats:sup>\n                      [SD 7659] to 14,288\u00a0mm\n                      <jats:sup>3<\/jats:sup>\n                      [SD 7418],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and patient body weight percentile declined significantly (48.4\u201344.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.016), although neither was linearly associated with radiation dose. There were non\u2010significant decreases in subcutaneous fat area standardized to height (38.6\u201336.9\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      \/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.41) and in tPMA\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores (\u22121.56 to \u22122.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.26).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients undergoing RT for abdominal HR\u2010NBL experienced significant pancreatic volume loss. This may place them at risk for pancreatic insufficiency. Patients also had significant decreases in weight percentile with corresponding non\u2010significant decreases in subcutaneous fat and psoas muscle area. Further research is needed to characterize the association of these findings with pancreatic function and nutritional status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70305","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T13:04:56Z","timestamp":1775394296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pancreas, Muscle, and Subcutaneous Fat Atrophy in Patients Undergoing Radiation for Neuroblastoma"],"prefix":"10.1002","volume":"73","author":[{"given":"Pradipta","family":"Debnath","sequence":"first","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4345-9531","authenticated-orcid":false,"given":"Marissa","family":"Ray","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Surgery University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Pater","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra O.","family":"Glenn","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-5238","authenticated-orcid":false,"given":"Elanchezhian","family":"Somasundaram","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Radiology University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Gurria","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery Cincinnati Children's Hospital 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