{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:31:48Z","timestamp":1793406708390,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population\u2010based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective, population\u2010based cohort study using the Cancer in Young People in Canada database of all children diagnosed with RB from 2001 to 2019. Primary outcomes were 5\u2010year overall survival (OS) and grade 3\u20134 complications. Univariate and multivariable regression analyses were performed to assess associations between clinical characteristics and the outcomes. Kaplan\u2013Meier survival analyses were conducted to estimate time\u2010to\u2010event outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 484 patients, the median age at diagnosis was 1.2 years (interquartile range: 0.4\u20132.2). Eight (1.7%) patients had metastatic disease at diagnosis, and 273 (56.4%) underwent enucleation. Overall, 96.1% of patients in the cohort were alive at last follow\u2010up. The cohort's 5\u2010year OS, as estimated by the Kaplan\u2013Meier method, was 94.2% (95% CI 90.8\u201396.3). Compared with localized disease, metastatic disease was associated with inferior 5\u2010year OS (12.5%\u00a0vs. 96.2%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Non\u2010White patients (vs. White patients) had inferior 5\u2010year OS (88.8%\u00a0vs. 96.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). The prevalence of grade 3 and 4 complications was 4.8% across the entire cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 31 events,\n                      <jats:italic>n<\/jats:italic>\n                      = 23 patients). Eight (1.7%) patients developed grade 3 or 4 hearing loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This large population\u2010based study reported few complications in children with RB but highlighted key survival disparities among non\u2010White patients and patients with metastatic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70316","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:41:11Z","timestamp":1776062471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population\u2010Based Report From CYP\u2010C"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-7547","authenticated-orcid":false,"given":"Samuel","family":"Sassine","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology, Department of Pediatrics Charles\u2010Bruneau Cancer Center, CHU Sainte\u2010Justine  Montreal Quebec Canada"},{"name":"CHU Sainte\u2010Justine Azrieli Research Center  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Of\u00e9lie","family":"Trudeau\u2010Ferrin","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Justine Azrieli Research Center  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Laverdi\u00e8re","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology, Department of Pediatrics Charles\u2010Bruneau Cancer Center, CHU Sainte\u2010Justine  Montreal Quebec 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