{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:22:22Z","timestamp":1783113742290,"version":"3.54.6"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Although not always achieved, complete chemotherapy\u2010induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two\u2010center, mixed\u2010methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints. We also aimed to describe their CINV experience, CINV management strategies, and openness to learning new antiemetic interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>English\u2010speaking patients with acute lymphoblastic leukemia (ALL) (13\u201318 years), or family caregivers of patients with ALL (&lt;18 years), with a history of moderate to severe CINV and who were in or had recently completed maintenance treatment were eligible. We conducted semi\u2010structured, virtual, or in\u2010person interviews with participants using an interview guide. Interviews included direct questions and open\u2010ended questions asking participants to think\u2010aloud. Interviews were audio\u2010recorded and transcribed verbatim. Direct question response proportions were determined. Thematic analysis of the responses to open\u2010ended questions was undertaken.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010nine interviews (23 caregivers and 6 adolescent patients) were conducted. Participants reported that reductions in nausea frequency (caregivers: 77%; adolescent patients: 83%) and severity (caregivers: 85%; adolescent patients: 83%), even without complete resolution, were very important. Responses regarding vomiting control were similar. Patients and caregivers also believed that preservation of appetite and maintenance of diet and usual activities were important CINV control endpoints. Major themes emerged revealing the creativity and resilience shown by patients and caregivers in their CINV management approaches. Almost all patients and caregivers were interested in learning new strategies for CINV control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antiemetic interventions should be evaluated using both conventional CINV control endpoints and those that are important to patients and caregivers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70332","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:39:22Z","timestamp":1775911162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preferences of Pediatric Patients and Their Caregivers for Chemotherapy\u2010Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3022-8052","authenticated-orcid":false,"given":"Haley","family":"Newman","sequence":"first","affiliation":[{"name":"Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadi","family":"Hondonga","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Berry","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-3031","authenticated-orcid":false,"given":"Caitlin","family":"Elgarten","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-2701","authenticated-orcid":false,"given":"Jason","family":"Freedman","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6635-3991","authenticated-orcid":false,"given":"Katelyn","family":"Oranges","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"McDonough","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8005-3836","authenticated-orcid":false,"given":"Caroline","family":"Diorio","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-1061","authenticated-orcid":false,"given":"L. Lee","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Pharmacy, The Hospital for Sick Children and Leslie Dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e3182281493"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29876"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16386"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08623-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27646"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2019-002022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732309354278"},{"key":"e_1_2_8_10_1","volume-title":"Transforming Qualitative Information: Thematic Analysis and Code Development","author":"Boyatzis R. 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