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This review provides an overview of potential drug\u2013drug interactions between cannabinoids and 25 antineoplastic agents commonly used in pediatric hematology\/oncology. Antineoplastic agents were stratified into low, medium, or high interaction risk based on the potential impact of cannabinoids on metabolic and\/or pharmacodynamic pathways. The antineoplastic agents identified as high risk for interactions with cannabinoids included cyclophosphamide, doxorubicin, etoposide, ifosfamide, irinotecan, vinblastine, and vincristine. Key mechanisms of interaction include inhibition of cytochrome P450 enzymes and UDP\u2010glucuronosyltransferases and modulation of drug transporters such as P\u2010glycoprotein and breast cancer resistance protein. There is emerging evidence of a synergistic effect between cannabinoids and antineoplastic agents such as temozolomide, vinblastine, vinorelbine, and irinotecan. Pediatric patients exhibit developmental differences in drug metabolism and transporter expression, yet most pharmacokinetic data on cannabinoids are extrapolated from adult studies. There is a lack of pediatric\u2010specific safety, efficacy, and dosing data that underscores the need for age\u2010appropriate studies to ensure safe and effective integration of cannabinoids in pediatric cancer care.<\/jats:p>","DOI":"10.1002\/1545-5017.70336","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:29:57Z","timestamp":1777530597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Overview of Cannabinoid Interactions With Common Pediatric Antineoplastic Agents"],"prefix":"10.1002","volume":"73","author":[{"given":"Shatila","family":"Zaman","sequence":"first","affiliation":[{"name":"University of Michigan College of Pharmacy  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie","family":"Schatz","sequence":"additional","affiliation":[{"name":"Texas A&amp;M College of Pharmacy  College Station Texas 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