{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:24:44Z","timestamp":1783113884782,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Langerhans cell histiocytosis (LCH) is a rare clonal myeloid neoplasm. Cardiac involvement is exceedingly uncommon in neonates. We report a term male neonate with prenatally detected pericardial effusion and a postnatally identified epicardial mass adherent to the left ventricle. Multimodal imaging demonstrated confinement to the visceral pericardium without myocardial infiltration. Biopsy confirmed LCH (CD1a\n                    <jats:sup>+<\/jats:sup>\n                    , CD207\n                    <jats:sup>+<\/jats:sup>\n                    , S\u2010100\n                    <jats:sup>+<\/jats:sup>\n                    , ALK\n                    <jats:sup>\u2013<\/jats:sup>\n                    , BRAFV600E\n                    <jats:sup>\u2013<\/jats:sup>\n                    ) and staging excluded systemic disease. The patient remained hemodynamically stable and was managed conservatively after multidisciplinary evaluation. Serial imaging demonstrated complete spontaneous regression by 6\u00a0months. Comprehensive staging and precise anatomical imaging can guide safe observation in isolated epicardial LCH.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70356","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:44:12Z","timestamp":1776681852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated Epicardial Langerhans Cell Histiocytosis in a Neonate With Complete Spontaneous Regression"],"prefix":"10.1002","volume":"73","author":[{"given":"Lucas Oliveira","family":"Rocha","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Hospital Pequeno Principe  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7098-308X","authenticated-orcid":false,"given":"Ana Paula Kuczynski Pedro","family":"Bom","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Hospital Pequeno Principe  Curitiba Brazil"},{"name":"Department of Pediatrics Pontifical Catholic University of Parana (PUCPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-8423","authenticated-orcid":false,"given":"Milen","family":"Minkov","sequence":"additional","affiliation":[{"name":"Clinical Trial Unit, CCRI, St. Anna Kinderkrebsforschung  Vienna Austria"},{"name":"Center of Child Health, Growth, and Development Sigmund Freud University  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1607548"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000934"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.25604"},{"key":"e_1_2_8_5_1","volume-title":"Pericardial Effusion in a 16\u2010Month\u2010Old Child With Langerhans Cell Histiocytosis","author":"Keelie B.","year":"2013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03320160042030"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003507"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002766"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90127-2"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"S1309","article-title":"Congenital Self\u2010Healing Langerhans Cell Histiocytosis With Pulmonary Involvement: Spontaneous Regression","volume":"85","author":"Chunharas A.","year":"2002","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441809"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31815cc3d7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.3.301"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00055-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2017.08.018"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00466"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15577"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.9508"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14695"}],"container-title":["Pediatric Blood &amp; 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