{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:25:15Z","timestamp":1783463115247,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The t(1;22)(p13;q13) chromosome abnormality is reported in 10%\u201317% of children with acute megakaryoblastic leukemia (AMKL), leading to the chimeric fusion gene\n                      <jats:italic>RBM15<\/jats:italic>\n                      ::\n                      <jats:italic>MRTFA<\/jats:italic>\n                      . Previous studies have revealed that AMKL with t(1;22) exhibits a good prognosis; however, early death has been observed in cases with onset of the disease at birth and liver failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To determine the clinical characteristics and outcomes of AMKL with t(1;22), we conducted a nationwide retrospective survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AMKL with t(1;22) was diagnosed in 23 children (eight boys and 15 females) from 2000 to 2013. Their median age at diagnosis was 4\u00a0months (range: 0\u201334\u00a0months). Hepatosplenomegaly was observed in 17 patients, with three initially misdiagnosed as solid tumors. G\u2010banding revealed t(1;22) in 21 patients, and PCR detected the\n                      <jats:italic>RBM15<\/jats:italic>\n                      ::\n                      <jats:italic>MRTFA<\/jats:italic>\n                      fusion gene in two other patients. The 5\u2010year overall survival (OS)\/event\u2010free survival (EFS) rates in all patients were 52%\/35%. Eight patients aged less than 6\u00a0months at diagnosis and had hepatomegaly (\u22656\u00a0cm under the right hypochondrium) demonstrated significantly lower 5\u2010year OS\/EFS rates (25%\/0%) than the remaining 15 patients (67% [\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008]\/25% [\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001]). Among 16 patients treated with intensive chemotherapy, the 5\u2010year OS\/EFS rates were significantly higher (63%\/44%) than those of seven patients who did not receive such treatment (29% [\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04]\/14% [\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that previously reported data may have overestimated the prognosis of AMKL with t(1;22). Infants aged less than 6\u00a0months with severe hepatosplenomegaly demonstrated poor outcomes, and thus AMKL with t(1;22) should be suspected to initiate appropriate chemotherapy immediately.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70361","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:44:57Z","timestamp":1779709497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Outcomes of Acute Megakaryoblastic Leukemia With t(1;22)(p13;q13) in Children"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7582-0201","authenticated-orcid":false,"given":"Asahito","family":"Hama","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Children's Medical Center Japanese Red Cross Aichi Medical Center Nagoya First Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-9568","authenticated-orcid":false,"given":"Daisuke","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiichiro","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Taga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Human Health Sciences Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Division of Leukemia and Lymphoma Children's Cancer Center National Centre for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-567859"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqy074"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3727"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403815"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06971.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2383-2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18691"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3772"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.3.748.748"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509075307"},{"issue":"2","key":"e_1_2_12_12_1","first-page":"608","article-title":"Distinctive Demography, Biology, and Outcome of Acute Myeloid Leukemia and Myelodysplastic Syndrome in Children With Down Syndrome: Children's Cancer Group Studies 2861 and 2891","volume":"91","author":"Lange B. 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