{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:22:05Z","timestamp":1783113725214,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We examined the impact of the treatment centre volumes (number of patients per centre) on the management and outcomes of rhabdomyosarcoma (RMS) patients enrolled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed 1613 patients with localised RMS treated from 2005 to 2016 in 126 European centres classified as high\u2010, medium\u2010, or low\u2010volume according to the number of patients enrolled in the RMS 2005 protocol coordinated by the European\n                      <jats:italic>paediatric<\/jats:italic>\n                      Soft tissue sarcoma Study Group (E\n                      <jats:italic>p<\/jats:italic>\n                      SSG). We evaluated diagnostic and treatment indicators, protocol adherence and survival outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Patients\u2019 demographic and tumour characteristics were overall comparable across groups, though high\u2010volume centres treated more patients with advanced disease. Diagnostic work\u2010up largely adhered to protocol recommendations, with minor differences: high\u2010volume centres showed greater adherence to central pathology review (77.7%) and molecular testing (76.2%), while medium\u2010volume centres used\n                      <jats:sup>18<\/jats:sup>\n                      FDG\u2010PET\/CT more frequently (39.7%). Risk group misclassification occurred in 4.5% of patients, more often in low\u2010volume centres. Other treatment quality indicators, including surgical margins, chemotherapy adherence, radiotherapy administration, and participation in the randomised trials, were comparable among groups. Five\u2010year event\u2010free survival and overall survival did not differ significantly between groups, including high\u2010risk subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the treatment of paediatric RMS, adherence to standardised treatment protocols ensures consistent outcomes across centres of varying volumes. Observed differences in specific diagnostic processes highlight the importance of fostering international collaboration and drawing on the expertise of high\u2010volume centres to enhance the quality of care and outcomes for paediatric RMS patients. The adoption of a standardised international protocol would help standardise care and outcomes across Europe, thereby minimising geographical disparities and ensuring equitable access to high\u2010quality treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70373","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:19:08Z","timestamp":1777979948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Centres With Different Patient Volume on Diagnostic Process, Therapeutic Strategy and Outcome in Patients With Localised Rhabdomyosarcoma: A Report From the European\n                    <i>paediatric<\/i>\n                    Soft tissue sarcoma Study Group (E\n                    <i>p<\/i>\n                    SSG)"],"prefix":"10.1002","volume":"73","author":[{"given":"Maria Carmen","family":"Affinita","sequence":"first","affiliation":[{"name":"Paediatric Hematology Oncology and Stem Cell Transplant Division Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-8960","authenticated-orcid":false,"given":"Maja","family":"Cesen","sequence":"additional","affiliation":[{"name":"University Children's Hospital Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mudry","sequence":"additional","affiliation":[{"name":"University Children's Hospital Brno  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Devalck","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology H\u00f4pital Universitaire des Enfants Reine Fabiola Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heide","family":"Glosli","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Rare Diseases Division of Paediatric and Adolescent Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Coppadoro","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Zanetti","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Minard\u2010Colin","sequence":"additional","affiliation":[{"name":"Gustave Roussy Department of Paediatric and Adolescent Oncology Universit\u00e9 Paris\u2010Saclay  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Children and Young Peoples Unit Royal Marsden Hospital and Institute of Cancer Research  Sutton Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-139X","authenticated-orcid":false,"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[{"name":"SIREDO Oncology Centre (Care Innovation and Research for Children Adolescents and Young Adults with Cancer) Institut Curie  Paris France"},{"name":"Universit\u00e9 Paris Sciences et Lettres  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Terwisscha van Scheltinga","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Paediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4729-825X","authenticated-orcid":false,"given":"Raquel Davila","family":"Fajardo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Medical Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1000-3534","authenticated-orcid":false,"given":"Lise","family":"Borgwardt","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes H. 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