{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:22:22Z","timestamp":1783113742296,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children with Down syndrome (DS) have a markedly increased risk of myeloid leukemia (ML\u2010DS). While survival rates approach 90% in high\u2010income settings, treatment\u2010related toxicity remains a critical challenge in other regions. This study evaluated overall survival (OS), event\u2010free survival (EFS), cumulative incidence of relapse (CIR), and treatment\u2010related mortality (TRM) in pediatric patients with ML\u2010DS in Argentina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective study of 49 patients with ML\u2010DS (\u226418\u00a0years) treated between 2008 and 2025. All patients were treated with the GATLA 8\u2010LMAP\u20102007 protocol, a reduced\u2010intensity regimen based on AML\u2010BFM 98 (four chemotherapy cycles with reduced anthracyclines, omission of high\u2010dose cytarabine and mitoxantrone, eight intrathecal doses, and 1\u2010year maintenance). We did not use cranial irradiation and hematopoietic stem cell transplantation. Survival was estimated using the Kaplan\u2013Meier method, and comparisons were performed using the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We enrolled 49 patients with ML\u2010DS in this study. Most patients were \u22642\u00a0years old (59.2%) and presented with the FAB M7 subtype (75.5%). At 48\u00a0months, the CIR was 6.9% (standard error [SE] 3.9), and TRM was 12.5% (SE 4.8). Both 48\u2010month EFS and OS were 80.3% (SE 5.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this Argentine cohort, ML\u2010DS treated with an adapted reduced\u2010intensity protocol achieved favorable survival outcomes. However, the TRM of 12.5% highlights the ongoing need to optimize supportive care and further refine strategies to reduce treatment\u2010related toxicity in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70375","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:58:03Z","timestamp":1777885083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Myeloid Leukemia Associated With Down Syndrome Treated With a Reduced\u2010Intensity Protocol: A Multicenter Experience in Argentina"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2906-1669","authenticated-orcid":false,"given":"Alejandra","family":"Deana","sequence":"first","affiliation":[{"name":"Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6198-9778","authenticated-orcid":false,"given":"Sergio Miguel","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena Elizabeth","family":"Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-4731","authenticated-orcid":false,"given":"Maria S.","family":"Felice","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda S.A.M.I.C. Prof. Dr. Juan P. Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6867-9968","authenticated-orcid":false,"given":"Riccheri","family":"Cecilia","sequence":"additional","affiliation":[{"name":"Hospital Nacional Dr. A. Posadas  Mor\u00f3n Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8938-5631","authenticated-orcid":false,"given":"Ferraro Cristina","family":"Luciana","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1811-8521","authenticated-orcid":false,"given":"Martinez","family":"Gabriela","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Dr. Pedro Elizalde  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8593-6787","authenticated-orcid":false,"given":"Goldman","family":"Wanda","sequence":"additional","affiliation":[{"name":"Hospital Sor Maria Ludovica\u2010La Plata  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1157-3395","authenticated-orcid":false,"given":"Hollmann","family":"Carlos","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os de La Santisima Trinidad y Hospital Privado de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2166-6587","authenticated-orcid":false,"given":"Arbes\u00fa Mario","family":"Guillermo","sequence":"additional","affiliation":[{"name":"Instituci\u00f3n Hospital Pediatrico Dr. Humberto Notti  Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3595-3207","authenticated-orcid":false,"given":"Ruiz","family":"Claudia","sequence":"additional","affiliation":[{"name":"Nueva Clinica del Ni\u00f1o de La Plata  La Plata Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drozdowski","family":"Constanza","sequence":"additional","affiliation":[{"name":"Instituci\u00f3n Cl\u00ednica San Lucas  Neuqu\u00e9n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasetti","family":"Mercedes","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Victor J. Vilela  Rosario Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0844-3911","authenticated-orcid":false,"given":"Manni","family":"Federico","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Orlando Alassia  Mendoza, Santa F\u00e9 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0009-5507","authenticated-orcid":false,"given":"Arrieta Maria","family":"Elizabeth","sequence":"additional","affiliation":[{"name":"Hospital P\u00fablico Dr. Guillermo Rawson  San Juan Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deu","family":"Alejandra","sequence":"additional","affiliation":[{"name":"Hospital Materno Infantil San Roque  Paran\u00e1, Entre R\u00edos Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3524-8830","authenticated-orcid":false,"given":"Navarro Guitart","family":"Roberto","sequence":"additional","affiliation":[{"name":"Hospital Municipal Infantil de Cordoba  Cordoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3357-5578","authenticated-orcid":false,"given":"Caferri","family":"Horacio","sequence":"additional","affiliation":[{"name":"Hospital Italiano Regional del Sur  Bahia Blanca Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil Mar\u00eda","family":"Gimena","sequence":"additional","affiliation":[{"name":"Hospital Interzonal Dr. J. 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