{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:22:59Z","timestamp":1783113779179,"version":"3.54.6"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long\u2010term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during critical developmental periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eight children treated for ALL (aged 6\u201312 years) completed a supervised INT intervention (2 sessions\/week for 8 weeks). Primary outcomes were feasibility (recruitment, retention, adherence, compliance, and tolerance) and program acceptability. Secondary outcomes included muscle function (isometric midthigh pull [IMTP], countermovement jump, and handgrip strength), dual\u2010energy x\u2010ray absorptiometry (DXA)\u2010derived body composition, peripheral quantitative computed tomography (pQCT)\u2010derived muscle measures, and health\u2010related quality of life assessed using the Pediatric Quality of Life Inventory (PedsQL). Pre\u2010 to post\u2010intervention changes were evaluated using paired tests (paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests or Wilcoxon signed\u2010rank tests, depending on normality) and corresponding effect sizes (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      or rank\u2010biserial correlation).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recruitment was 80%, retention was 100%, and adherence was 100%, although the intervention extended beyond 8 weeks. The program was well\u2010tolerated and demonstrated high acceptability, with no adverse events reported. Exploratory analyses suggested improvements in muscle strength (IMTP and countermovement jump peak force, and left handgrip strength), modest increases in whole\u2010body lean mass, and specific PedsQL domains (school functioning, general fatigue, cognitive fatigue), with limited changes in muscle power and pQCT\u2010derived muscle measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>INT is feasible and acceptable for survivors of childhood ALL, though maintaining twice\u2010weekly attendance was challenging. Preliminary results indicate potential benefits for muscle strength, mass, and specific quality\u2010of\u2010life domains, underscoring the need for strategies to support consistent participation in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70377","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:45:07Z","timestamp":1777981507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and Preliminary Efficacy of Integrative Neuromuscular Training for Childhood Cancer Survivors: A Pilot Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-1544","authenticated-orcid":false,"given":"Anna Maria","family":"Markarian","sequence":"first","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-6129","authenticated-orcid":false,"given":"Robert U.","family":"Newton","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis R.","family":"Taaffe","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1082-6776","authenticated-orcid":false,"given":"Nicholas G.","family":"Gottardo","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Oncology\/Haematology Perth Children's Hospital  Nedlands Western Australia Australia"},{"name":"Brain Tumour Research Program The Kids Institute Australia  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9655-0001","authenticated-orcid":false,"given":"Santosh","family":"Valvi","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Oncology\/Haematology Perth Children's Hospital  Nedlands Western Australia Australia"},{"name":"Brain Tumour Research Program The Kids Institute Australia  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J.","family":"Peddle\u2010McIntyre","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-9579","authenticated-orcid":false,"given":"Jodie Cochrane","family":"Wilkie","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Physical Activity, Sport and Exercise Research Theme, Faculty of Health Southern Cross University  Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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