{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:25:51Z","timestamp":1783463151047,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) is a rare cytotoxic T\u2010cell lymphoma, and pediatric cases are uncommon, with available literature limited to case reports and small series. We conducted a scoping review in accordance with PRISMA guidelines, systematically searching PubMed, Embase, Cochrane Library, and Google Scholar from inception to December 31, 2025. Studies reporting pediatric patients with SPTCL were included. Thirty\u2010four studies comprising\n                    <jats:italic>114 pediatric patients<\/jats:italic>\n                    were included. Most children presented with\n                    <jats:italic>subcutaneous nodules or plaques<\/jats:italic>\n                    , and the disease was\n                    <jats:italic>localized to the skin<\/jats:italic>\n                    in the majority.\n                    <jats:italic>B symptoms<\/jats:italic>\n                    and\n                    <jats:italic>hemophagocytic lymphohistiocytosis (HLH)<\/jats:italic>\n                    were frequently reported and were associated with more severe disease. First\u2010line treatment varied widely, with\n                    <jats:italic>chemotherapy used in 57.4%, immunosuppressive therapy in 34.7%<\/jats:italic>\n                    , and\n                    <jats:italic>observation in 7.9%<\/jats:italic>\n                    of patients.\n                    <jats:italic>Salvage therapy<\/jats:italic>\n                    was required in approximately 21% of patients, and\n                    <jats:italic>hematopoietic stem cell transplantation<\/jats:italic>\n                    was reserved for a small subset with refractory or relapsed disease. Total\n                    <jats:italic>84.3% patients achieved sustained remission<\/jats:italic>\n                    . Mortality was reported in\n                    <jats:italic>10.8%<\/jats:italic>\n                    , largely in association with progressive disease or systemic complications. Pediatric SPTCL is a clinically heterogeneous disease with generally favorable outcomes. The presence of HLH identifies a higher risk subgroup requiring more intensive therapy. Risk\u2010adapted treatment strategies and collaborative prospective studies are needed to optimize management in children.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70396","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:04:08Z","timestamp":1778576648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics, Management, and Outcomes of Pediatric Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma: A Scoping Review"],"prefix":"10.1002","volume":"73","author":[{"given":"Sanjana","family":"Sarangarajan","sequence":"first","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-5339","authenticated-orcid":false,"given":"Amitabh","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdish Prasad","family":"Meena","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-8944","authenticated-orcid":false,"given":"Aditya Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7746-547X","authenticated-orcid":false,"given":"Rachna","family":"Seth","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12452"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25626"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00305.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.193909"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13053"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513815.2012.701264"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/639240"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001954"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201005045\u20104"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02575-4"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13684"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1607036"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14017"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12776"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24462"},{"issue":"2","key":"e_1_2_12_18_1","first-page":"48","article-title":"Subcutaneous Panniculitis\u2010Like T Cell Lymphoma Diagnosed with a Slowly Progressive Course: A Case Report","volume":"49","author":"Kawamura H.","year":"2024","journal-title":"Tokai Journal of Experimental and Clinical Medicine"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.045"},{"key":"e_1_2_12_20_1","first-page":"2025","article-title":"Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma in Children: Two Case Reports","volume":"18","author":"Mitura\u2010Lesiuk 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