{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:25:57Z","timestamp":1783463157529,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dexmedetomidine, an \u03b12 agonist, offers sustained, reversible sedation with anxiety and pain relief and reduces respiratory depression risk. This study assessed oral dexmedetomidine's efficacy and safety in pediatric acute lymphoblastic leukemia (ALL) patients during blood draws.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized, double\u2010blinded, prospective clinical trial involved 60 pediatric patients aged 2\u201318\u00a0years diagnosed with ALL in the maintenance phase. Subjects were randomly assigned to either the intervention group, receiving 1.5\u00a0\u00b5g\/kg oral dexmedetomidine mixed in apple juice, or the control group, receiving apple juice only. Sedation depth, as measured by the Richmond Agitation\u2010Sedation Scale (RASS), pain intensity, as assessed by the Face, Legs, Activity, Cry, Consolability (FLACC) scale and Numeric Rating Scale (NRS), and hemodynamic parameters (heart rate, blood pressure, and SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) were evaluated at baseline, and at 10\u2010, 20\u2010, and 30\u2010min post\u2010administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences were observed between the two groups with respect to age or weight. Oxygen saturation and blood pressure were similar across all time points. A statistically significant decrease in heart rate was noted at 30\u00a0min in the dexmedetomidine group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). Furthermore, pain intensity during blood sampling was significantly lower in the intervention group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). RASS scores at 20 and 30\u00a0min indicated a greater degree of sedation in the dexmedetomidine group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral dexmedetomidine effectively reduced pain and anxiety during blood draws in pediatric leukemia patients without significant adverse effects, suggesting its safety and efficacy as a pre\u2010procedural sedative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70400","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:26:29Z","timestamp":1778822789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sedation With Oral Dexmedetomidine Premedication in Pediatric Patients With Acute Lymphoblastic Leukemia Undergoing Blood Sampling: A Randomized, Double\u2010Blind Clinical Trial"],"prefix":"10.1002","volume":"73","author":[{"given":"Farshad","family":"Khoddami","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Naderisorki","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center (TRC) Hemoglobinopathy Institute Mazandaran University of Medical Sciences  Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-6732","authenticated-orcid":false,"given":"Monireh","family":"Ghazaeian","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center Department of Clinical Pharmacy Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Karami","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center (TRC) Hemoglobinopathy Institute Mazandaran University of Medical Sciences  Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Salehifar","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center Department of Clinical Pharmacy Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Hosseinnataj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Health Mazandaran University of Medical Sciences  Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S346089"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14379"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_491_19"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03114.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/614784"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5935\/2595-0118.20220004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.101341"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2021.05.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-023-00485-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039337"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-020-00900-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.872900"},{"issue":"1","key":"e_1_2_9_14_1","first-page":"16","article-title":"A Comparison of Administration of Oral Chloral Hydrate With Intranasal Dexmedetomidine in Sedation of Children to Perform Electroencephalography","volume":"43","author":"Borhani M.","year":"2021","journal-title":"Med"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10030454"},{"issue":"5","key":"e_1_2_9_16_1","article-title":"Dexmedetomidine for Analgesia and Sedation in Newborn Infants Receiving Mechanical Ventilation","volume":"2024","author":"Lim J. 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