{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:59:39Z","timestamp":1791341979848,"version":"4.3.1"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Retinoblastoma management has changed notably in the past 11 years. Here, four retinoblastoma experts in the USA and Europe report their management recommendations. Retinoblastoma is now the most curable of all pediatric cancers in developed countries, and major clinical trials are scarce; thus, the experience of these centers carries important information for clinicians worldwide. There is increasing use of intra\u2010arterial chemotherapy for unilateral and bilateral disease in na\u00efve and recurrent eyes. Intravitreal chemotherapy is increasingly being used, and high\u2010dose topotecan for vitreous seeds, anterior chamber tumor (combined with intracameral injection), and recurrent retinal and subretinal tumors is becoming the standard approach.<\/jats:p>","DOI":"10.1002\/1545-5017.70401","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:06:26Z","timestamp":1778821586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How We Approach Intraocular Retinoblastoma in 2026: Agreement and Disagreement in Four Referral Centers in the USA and Europe"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-6391","authenticated-orcid":false,"given":"David H.","family":"Abramson","sequence":"first","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-3632","authenticated-orcid":false,"given":"Carol L.","family":"Shields","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service Wills Eye Hospital, Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-1050","authenticated-orcid":false,"given":"Francis L.","family":"Munier","sequence":"additional","affiliation":[{"name":"Jules\u2010Gonin Eye Hospital, Fondation Asile des Aveugles, Facult\u00e9 de Biologie et M\u00e9decine de Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-9336","authenticated-orcid":false,"given":"Guillermo","family":"Chantada","sequence":"additional","affiliation":[{"name":"Pediatric Cancer Center Barcelona Hospital Sant Joan De D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.3108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo\u20102022\u2010322866"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025792\u20100"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033248\u20102"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010016\u20103554\u20106"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(23)00141\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010021\u201002610\u2010z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102016\u2010309298"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02337"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01808"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.1501"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.19981"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.05.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30718"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.05.051"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2025.1079"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.12.015"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6590"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2025.03.008"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31821e9f8a"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.12.014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140539004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156806"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30352"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/tjo.TJO\u2010D\u201024\u201000107"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.4600"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080180074031"},{"key":"e_1_2_11_29_1","first-page":"86","article-title":"An Age\u2010Based Method for Planning Sclerotomy Placement During Pediatric Vitrectomy: A 12\u2010Year Experience","volume":"105","author":"Lemley C. A.","year":"2007","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2025.03.018"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000546729"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.04.010"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143392"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235016"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.03.028"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2025.100963"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201005\u20100849"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109026"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2024.11.010"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3928\/01913913\u201020230110\u201001"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004678"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo\u20102022\u2010322492"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2018.1443343"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102018\u2010312037"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2024.10.010"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2024.2388579"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_721_20"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102018\u2010312546"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010061312\u2010123455"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181923cc5"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102018\u2010312915"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002339"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.11.029"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.3962"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.03.018"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3928\/01913913\u201020240508\u201009"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2017.1393826"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2017.08.022"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2012.567"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.05.005"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2022.11.014"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22503"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2021.2004433"},{"issue":"8","key":"e_1_2_11_64_1","article-title":"Comparing Outcomes Amongst Primarily Enucleated Retinoblastoma Patients with Post\u2010Laminar Optic Nerve Infiltration Based on Adjuvant Chemotherapy","volume":"66","author":"Pike S.","year":"2025","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2023.6516"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:04:04Z","timestamp":1783461844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/1545-5017.70401"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70401","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70401"}}