{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:24:18Z","timestamp":1783463058361,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac monitoring in children receiving pathway\u2010directed anticancer therapies is largely extrapolated from adult cardio\u2010oncology practice. Developmental differences in cardiovascular physiology raise the possibility that treatment\u2010related cardiovascular toxicity may not present similarly across ages. Whether the pattern of cardiovascular adverse events associated with these therapies differs between children and adults remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective pharmacovigilance study using VigiBase, the World Health Organization global database of individual case safety reports (March 2025 extract). Reports involving pathway\u2010directed anticancer therapies, including kinase and proteasome inhibitors, were classified as minors (&lt;18\u00a0years) or adults (\u226518\u00a0years). Cardiovascular adverse events were identified using predefined terms. Within\u2010drug disproportionality analyses adjusted for sex were performed with age\u2010stratified and indication\u2010matched sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 5097 pediatric and 273,833 adult reports were analyzed. Cardiovascular reporting patterns differed markedly between age groups. Vascular and ischemic complications and supraventricular arrhythmias were rarely reported in children. In contrast, pediatric reports were predominantly characterized by myocardial dysfunction, including decreased ejection fraction and heart failure, with occasional repolarization abnormalities. Findings were consistent across pediatric age groups and after adjustment for concomitant cardiotoxic therapies, including anthracyclines. Limited drug\u2013event associations were observed for selected agents, mainly involving myocardial dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These therapies showed an age\u2010dependent pattern of cardiovascular adverse event reporting, predominantly myocardial in children and vascular\u2010ischemic in adults. Pediatric cardiac surveillance should therefore prioritize assessment of myocardial function during treatment rather than directly mirroring adult monitoring strategies. Prospective studies with standardized cardiac evaluation are needed to inform age\u2010adapted monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70413","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:59:08Z","timestamp":1779091148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Dependent Cardiovascular Adverse Event Reporting With Pathway\u2010Directed Anticancer Therapies in Children and Adults: A VigiBase Disproportionality Analysis"],"prefix":"10.1002","volume":"73","author":[{"given":"Fabien","family":"Labombarda","sequence":"first","affiliation":[{"name":"Department of Cardiology Normandie University, PSIR UNICAEN, CHU Caen\u2010Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bodet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology CHU de Caen\u2010Normandie  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-8832","authenticated-orcid":false,"given":"J\u00e9r\u00e9mie","family":"Rouger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology CHU de Caen\u2010Normandie  Caen France"},{"name":"Imaging and Therapeutic Strategies for Cancers and Cerebral Tissues (ISTCT), Mixed Research Unit (UMR) 6030, OncoCARE Group  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie CHU Caen\u2010Normandie  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Sassier","sequence":"additional","affiliation":[{"name":"Department of Pharmacology CHU de Caen\u2010Normandie  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basile","family":"Chr\u00e9tien","sequence":"additional","affiliation":[{"name":"International Medical Education Department, Graduate School of Medicine Nagoya University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Alexandre","sequence":"additional","affiliation":[{"name":"PICARO Cardio\u2010Oncology Program, Department of Cardiology CHU de Caen\u2010Normandie  Caen France"},{"name":"Normandie Univ, UNICAEN, INSERM U1086 ANTICIPE  Caen France"},{"name":"PICARO Cardio\u2010Oncology Program, Department of Pharmacology CHU de Caen\u2010Normandie  Caen France"},{"name":"Department of Pharmacology 3 CHU de Caen\u2010Normandie, Centre R\u00e9gional de Pharmacovigilance  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Dolladille","sequence":"additional","affiliation":[{"name":"Department of Pharmacology 3 CHU de Caen\u2010Normandie, Centre R\u00e9gional de Pharmacovigilance  Caen France"},{"name":"Department of Pharmacology, 2 AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, CIC\u20101421, INSERM, UMR ICAN 1166 Sorbonne Universit\u00e9, APHP.6 Cardio\u2010Oncology Program  Paris 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