{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:18:08Z","timestamp":1787761088427,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pediatric low\u2010grade gliomas (pLGG) are the predominant childhood central nervous system tumors. While\n                    <jats:italic>BRAF<\/jats:italic>\n                    alterations are known to drive the majority of pLGGs, a subgroup contains activating mutations or fusions involving\n                    <jats:italic>FGFR1\/2\/3<\/jats:italic>\n                    . FGFR is a receptor tyrosine kinase that plays a crucial role in cell growth, differentiation, and survival through interactions with fibroblast growth factors. Furthermore, FGFR has been shown to interact with the RAS\/MAPK, PI3K\/AKT, and JAK\/STAT pathways. The current understanding of the biological behavior, clinical trajectory, and effectiveness of targeted inhibition in\n                    <jats:italic>FGFR<\/jats:italic>\n                    \u2010altered gliomas is notably limited. We sought to define the epidemiologic characteristics, molecular features, radiographic and histologic characteristics, and clinical course of patients with\n                    <jats:italic>FGFR<\/jats:italic>\n                    \u2010altered pLGGs. We also explored the therapeutic implications of these abnormalities in pediatric cases and highlight both current and emerging treatment strategies for pediatric patients with\n                    <jats:italic>FGFR<\/jats:italic>\n                    \u2010altered cancers.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70438","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:07:41Z","timestamp":1785380861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characterization of\n                    <i>FGFR<\/i>\n                    \u2010Altered Pediatric Low\u2010Grade Gliomas"],"prefix":"10.1002","volume":"73","author":[{"given":"Benjamin","family":"Posorske","sequence":"first","affiliation":[{"name":"School of Medicine\u2014Arizona A.T. Still University  Mesa Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Borden","sequence":"additional","affiliation":[{"name":"College of Medicine\u2014Phoenix University of Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shea","family":"Gallus","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Gilani","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Vaughn","sequence":"additional","affiliation":[{"name":"Department of Radiology Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Neuberger","sequence":"additional","affiliation":[{"name":"Department of Radiology Anschutz Medical Campus Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Keller","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theru A.","family":"Sivakumaran","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Azab","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M'hamed","family":"Temkit","sequence":"additional","affiliation":[{"name":"Department of Statistics and Epigenetics Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Dorris","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Anschutz Medical Campus Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Goldman","sequence":"additional","affiliation":[{"name":"College of Medicine\u2014Phoenix University of Arizona  Phoenix Arizona USA"},{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey M.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Mangum","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809342005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2682"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad149"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2022.100857"},{"key":"e_1_2_8_6_1","first-page":"750","article-title":"Pediatric Low\u2010Grade Gliomas: Implications of the Biologic Era","volume":"19","author":"Packer R.","year":"2017","journal-title":"Neuro\u2010Oncology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00902-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010141"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2780"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00222-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00390"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12071002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21288"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02705-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02255-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad078"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.268"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000213"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2020.e00153"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-023-05848-w"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264138"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26797"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7614"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2017.10.011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7465"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2020.102437"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad195"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1539-z"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2611"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6500"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225796"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61820-z"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308849"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00275-9"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02630"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.10007"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.10002"},{"key":"e_1_2_8_38_1","article-title":"Debio1347, an Oral FGFR Inhibitor: Results from a Single\u2010Center Study in Pediatric Patients With Recurrent or Refractory FGFR\u2010Altered Gliomas","volume":"5","author":"Farouk Sait S.","year":"2021","journal-title":"JCO Precision Oncology"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-020-03640-3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-020-03592-8"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.10"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70438","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:19:07Z","timestamp":1787757547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/1545-5017.70438"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70438","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70438"}}