{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:32:10Z","timestamp":1792589530556,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato\u2010cognitive coordination therapy (SCCT) is a virtual reality\u2013guided intervention designed to promote sensorimotor integration through visually constrained reaching tasks. We evaluated the safety, feasibility, and preliminary functional observations of SCCT in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective pilot study included 12 consecutive pediatric patients with cerebellar ataxia following brain tumor treatment who underwent outpatient SCCT between August 2023 and April 2025. SCCT sessions comprised approximately 10\u00a0min of alternating reaching tasks with limited visual feedback. Safety, acceptability, and changes in routinely documented selected scale for the assessment and rating of ataxia (SARA) subscale scores (gait, stance, and speech) were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients received a median of 1 SCCT session (range, 1\u20137). No serious adverse events occurred. Although two patients reported transient fatigue, all respondents expressed willingness to continue, and 11 patients (92%) spontaneously described the intervention as enjoyable. Preliminary functional changes were observed even after a single 10\u2010min session. The median pooled SARA subscale score showed a statistically significant reduction from 3.0 [interquartile range, 1.0\u20134.0] to 1.0 [1.0\u20132.0] (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). One patient with cerebellar mutism showed speech\u2010score reduction accompanied by longitudinal diffusion tractography changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SCCT appeared feasible and was not associated with serious adverse events in this retrospective pilot cohort. Exploratory functional observations warrant further evaluation in prospective randomized controlled trials to evaluate therapeutic efficacy and long\u2010term durability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This pilot study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN\u2010CTR), registration number: [UMIN000057736].<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70449","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:29:53Z","timestamp":1785382193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility and Safety of Somato\u2010Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1282-2812","authenticated-orcid":false,"given":"Masanobu","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsuzawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3193-3476","authenticated-orcid":false,"given":"Jun","family":"Yamanishi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6598-8694","authenticated-orcid":false,"given":"Masahiro","family":"Yoshitomi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Ichi","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuteru","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-9221","authenticated-orcid":false,"given":"Norio","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhroov","family":"Pathare","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0631-1534","authenticated-orcid":false,"given":"Masahiko","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Rehabilitation mediVR Rehabilitation Center  Toyonaka Japan"},{"name":"Centre for Community\u2010Based Healthcare Research and Education Shimane University Faculty of Medicine  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2021.1990900"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381\u2010021\u201005200\u20105"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npz004"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not164"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010230387"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31620"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102023\u2010259443"},{"key":"e_1_2_13_9_1","first-page":"697","article-title":"The Evaluations of Somato\u2013Cognitive Coordination Therapy Using Virtual Reality Technology for Children With Developmental Coordination Disorder Experiencing Difficulties in School Life","volume":"41","author":"Wagatsuma T.","year":"2024","journal-title":"Neurological 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Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:19:27Z","timestamp":1787757567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/1545-5017.70449"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70449","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2026-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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