{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:31:22Z","timestamp":1793287882266,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pediatric gastrointestinal stromal tumors (GISTs) are rare, often lacking\n                    <jats:italic>KIT<\/jats:italic>\n                    or platelet\u2010derived growth factor receptor\u2010alpha (\n                    <jats:italic>PDGFRA<\/jats:italic>\n                    ) mutations and driven by succinate dehydrogenase (SDH) deficiency. We report four pediatric patients (three females and one male) managed over a 19\u2010year period. Two female patients had SDH\u2010deficient tumors; one suffered metastatic relapse, illustrating the recurrent clinical course of this subtype. Of the two remaining cases, one SDH\u2010intact female remains in remission 8 years post\u2010diagnosis. The male patient demonstrated imatinib resistance but responded to sunitinib, facilitating gastrectomy. Despite a local recurrence managed by secondary wedge resection, he remains in remission. Comprehensive molecular profiling is essential for navigating GIST's clinical heterogeneity.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70453","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:21:46Z","timestamp":1785745306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Heterogeneity and Long\u2010Term Outcomes of Pediatric Gastrointestinal Stromal Tumors: A Series of Four Patients Highlighting SDH\u2010Deficient and SDH\u2010Intact Subtypes"],"prefix":"10.1002","volume":"73","author":[{"given":"Hala","family":"Elfarraj","sequence":"first","affiliation":[{"name":"Department of Pediatrics King Hussein Cancer Center  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2922-1937","authenticated-orcid":false,"given":"Maha","family":"Barbar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics King Hussein Cancer Center  Amman Jordan"},{"name":"Department of Pediatrics The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iyad","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics King Hussein Cancer Center  Amman Jordan"},{"name":"Department of Pediatrics The University of Jordan  Amman Jordan"},{"name":"Artificial Intelligence Office King Hussein Cancer Center  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-1976","authenticated-orcid":false,"given":"Hadeel","family":"Halalsheh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics King Hussein Cancer Center  Amman Jordan"},{"name":"Department of Pediatrics The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010199904000\u201000002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2006.09.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000338"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2018.07.08"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151538"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.27.5869"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009199108"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.05.033"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2024.07.011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244\u2010022\u201001193\u20109"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010021\u201004931\u20100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/children11091040"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2305\u20105839.2015.09.46"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0256"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70669"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000157790.81329.47"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010009\u20100044\u20100"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010018\u20101532\u20101"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14204989"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2016.09.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkArchPediatr.2024.24041"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010022\u201012582\u20101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.6733"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17040634"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2025\u2010070625"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32833aaae7"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2018.07.09"}],"container-title":["Pediatric Blood &amp; 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