{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:34:55Z","timestamp":1787758495199,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA272872"],"award-info":[{"award-number":["R01 CA272872"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care. However, often many of these genetic drivers are indicators of poor prognosis with no available targeted therapies. This is especially true for fusion\u2010positive pediatric sarcomas, which are driven by defining oncogenic fusions that are often intractable therapeutically. Additionally, many of these fusions have no cell, animal, or patient\u2010derived xenograft models to understand the biology of the human disease, hindering our ability to find new therapeutic opportunities. Here, we present strategies for linking personalized genomics to precision medicine approaches using zebrafish models as a proxy to understand human disease on a high\u2010throughput scale. Our vision for the future involves integrating this vertebrate model system to directly influence clinical care.<\/jats:p>","DOI":"10.1002\/1545-5017.70464","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:45:57Z","timestamp":1785383157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized Zebrafish Models for Fusion\u2010Positive Pediatric Sarcomas"],"prefix":"10.1002","volume":"73","author":[{"given":"Lisa H.","family":"Hall","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Center for Childhood Cancer Research The Abigail Wexner Research Institute Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma N.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Center for Childhood Cancer Research The Abigail Wexner Research Institute Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve C.","family":"Kendall","sequence":"additional","affiliation":[{"name":"Center for Childhood Cancer Research The Abigail Wexner Research Institute Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_200589"},{"key":"e_1_2_9_3_1","volume-title":"PDQ Cancer Information Summaries","year":"2002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050704"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16071355"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.11.3487"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2013.157"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2015.08.022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S193363"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12111"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914898"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00537-X"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.007401"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69734"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116376"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33800"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112013"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1545007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.001016"},{"issue":"7","key":"e_1_2_9_21_1","first-page":"907","article-title":"A Zebrafish Model of Chordoma Initiated by Notochord\u2010Driven Expression of HRASV12","volume":"7","author":"Burger A.","year":"2014","journal-title":"Disease Models & Mechanisms"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-04843-7_12"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0479-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.56"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.043"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68221"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406252102"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","unstructured":"C.Yan D. 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