{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:29Z","timestamp":1787761049812,"version":"build-2784847793"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Selumetinib, a mitogen\u2010activated protein kinase kinase inhibitor, was the first Food and Drug Administration\u2010approved treatment for children with neurofibromatosis type 1\u2010associated inoperable plexiform neurofibromas. We evaluated hematologic effects in 98 pediatric participants from the SPRINT Phase 1\/2 trial (NCT01362803) with a median follow\u2010up of 5.1 years (range: 0.2\u201311 years). Over 90% of values for white blood cell count, platelet count, absolute neutrophil count, and absolute lymphocyte count remained within normal limits across timepoints. There was a statistically significant, but unlikely clinically significant, decrease in absolute lymphocyte count and an increase in mean corpuscular volume. Selumetinib was not associated with apparent clinically significant hematologic changes.<\/jats:p>","DOI":"10.1002\/1545-5017.70477","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:32:47Z","timestamp":1785382367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Hematologic Effects of Selumetinib Treatment in Children With Neurofibromatosis Type 1\u2010Associated Plexiform Neurofibromas"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7438-037X","authenticated-orcid":false,"given":"Alan H.","family":"Siegel","sequence":"first","affiliation":[{"name":"Children's National Hospital  Washington District of Columbia USA"},{"name":"Pediatric Oncology Branch, Center for Cancer Research National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Clinical Research Directorate, Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc.  Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Heisey","sequence":"additional","affiliation":[{"name":"Clinical Research Directorate, Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc.  Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailey","family":"Herrera","sequence":"additional","affiliation":[{"name":"Clinical Research Directorate, Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc.  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