{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:46Z","timestamp":1787761066104,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number of ALL cases in pediatric patients, living in the Mexico City Metropolitan Area (MCMA), between 2010 and 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an ecological study including ALL cases coming from a pediatric hospital in the MCMA. Potential benzene emission sources were identified using data from the National Institute of Statistics and Geography. Multivariate spatial models estimated the effects of source number and type across buffers on the average number of ALL cases by municipality, sex, and age group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of sources within buffers related to the manufacture of petroleum and coal products, retail trade of fuels, oils, lubricants, printing industries, and chemical industry showed a statistically significant association with increased ALL incidence among children aged 2\u201317 years living in the MCMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests a positive association between the tight benzene source distances and the number of cases of ALL, and suggests more study for prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70482","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:32:21Z","timestamp":1785378741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010\u20132021: A Geospatial Analysis"],"prefix":"10.1002","volume":"73","author":[{"given":"Orlando Rivera","family":"Zurita","sequence":"first","affiliation":[{"name":"Alumno del Programa de Maestr\u00eda en Ciencias en Epidemiolog\u00eda Instituto Nacional de Salud P\u00fablica  Morelos Mexico"},{"name":"Subdirecci\u00f3n de Vigilancia Epidemiol\u00f3gica de los Servicios del Estado de Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Candelaria L\u00f3pez","family":"Santiago","sequence":"additional","affiliation":[{"name":"Departamento Hemato\u2010Oncolog\u00eda Instituto Nacional de Pediatr\u00eda Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Maria Garc\u00eda","family":"Cuellar","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n Instituto Nacional de Cancerolog\u00eda Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Maldonado","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento Hemato\u2010Oncolog\u00eda Instituto Nacional de Pediatr\u00eda Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7784-2287","authenticated-orcid":false,"given":"Nancy Reynoso","family":"Nover\u00f3n","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n Instituto Nacional de Cancerolog\u00eda Ciudad de M\u00e9xico Mexico"},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-2758","authenticated-orcid":false,"given":"Leticia Hern\u00e1ndez","family":"Cadena","sequence":"additional","affiliation":[{"name":"Departamento de Salud Ambiental Centro de Salud de la Poblaci\u00f3n Instituto Nacional de Salud P\u00fablica  Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"StatPearls","author":"Chennamadhavuni A.","year":"2023"},{"key":"e_1_2_12_3_1","volume-title":"Global Cancer Observatory: Cancer Today [Fact Sheet]","author":"Ferlay J.","year":"2024"},{"key":"e_1_2_12_4_1","volume-title":"Surveillance Research Program","author":"SEER*Explorer: An interactive website for SEER cancer statistics","year":"2025"},{"key":"e_1_2_12_5_1","volume-title":"Childhood Cancer Inequalities in the WHO European Region","author":"WHO","year":"2022"},{"key":"e_1_2_12_6_1","article-title":"Incidence of Childhood Cancer in Latin America and the Caribbean: Coverage, Patterns, and Time Trends","volume":"48","author":"Silva N.","year":"2024","journal-title":"Rev Panam Salud Publica"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a034819"},{"key":"e_1_2_12_8_1","volume-title":"Leukemia in Children, Childhood Leukemia"},{"key":"e_1_2_12_9_1","volume-title":"Protocolo de la atenci\u00f3n para leucemia linfobl\u00e1stica. Gu\u00eda cl\u00ednica y esquema de tratamiento [Report]","author":"Instituto Nacional de Salud P\u00fablica","year":"2013"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010020\u201002408\u2010y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.21149\/13210"},{"key":"e_1_2_12_12_1","volume-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay J.","year":"2024"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201006\u20100031"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp0900582"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000243849.82232.cb"},{"key":"e_1_2_12_16_1","volume-title":"Gu\u00eda de Pr\u00e1ctica Cl\u00ednica de diagn\u00f3stico y tratamiento de la Leucemia Mieloide Aguda [Report]","author":"Instituto Mexicano de Seguro Social","year":"2010"},{"issue":"1","key":"e_1_2_12_17_1","first-page":"129","article-title":"Environmental Risk Factors and Acute Lymphoblastic Leukemia in Childhood","volume":"15","author":"Pereira F. 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