{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:38Z","timestamp":1787761058102,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric bone sarcoma patients and survivors may experience psychosocial challenges related to childhood cancer after their intensive, body\u2010altering treatment. This cross\u2010sectional study aimed to evaluate generic and survivor\u2010specific psychosocial outcomes in a national cohort of pediatric bone sarcoma patients and survivors, and to explore associations between these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients treated for pediatric bone sarcoma, at least 2 years post\u2010diagnosis, completed age\u2010appropriate Pediatric Quality of Life Inventory (PedsQL) and PROMIS measures (generic outcomes). Patients \u226518 years additionally completed the impact of cancer\u2013childhood survivor (IOC\u2010CS) (survivor\u2010specific outcomes). Generic psychosocial outcomes of patients were compared with age\u2010 and sex\u2010specific Dutch normative data using one\u2010sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests. Linear regression analyses, adjusted for age and sex, examined associations between generic and survivor\u2010specific outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 139 patients participated (45% female). Mean age was 20.4 years (SD = 5.5) and mean time since end of treatment was 7.0 years (SD = 5.2). Patients scored significantly worse than normative values on cognitive functioning, pain interference, and health\u2010related quality of life. In other generic domains, such as depressive symptoms or anxiety, patients scored comparably to or better than normative values. Survivor\u2010specific outcomes were most positive in the socializing domain and most negative in the thinking and memory domain. Approximately 20% reported moderate\u2010to\u2010severe negative impact in at least one survivor\u2010specific domain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, pediatric bone sarcoma patients demonstrated psychosocial outcomes comparable to or more favorable than normative values. However, specific domains showed worse outcomes. In addition, a substantial subgroup experienced moderate\u2010to\u2010severe negative impacts of childhood cancer. This highlights the importance of monitoring psychosocial functioning and, where indicated, targeted interventions to address challenges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70487","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:53:03Z","timestamp":1785383583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychosocial Functioning After Pediatric Bone Sarcoma: Generic and Survivor\u2010Specific Outcomes in Adolescent and Young Adult Patients"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-5036","authenticated-orcid":false,"given":"Hinke","family":"van der Hoek","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen","family":"Maurice\u2010Stam","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura R.","family":"Beek","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein E. M.","family":"Langemeijer","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Relinde W.","family":"Slooff\u2010Lentink","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alied M.","family":"van der Aa\u2010van Delden","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Westerweel","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"van Gorp","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik W. B.","family":"Schreuder","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"},{"name":"Radboud University Medical Center Nijmegen  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-8906","authenticated-orcid":false,"given":"Lianne M.","family":"Haveman","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Peter","family":"Bekkering","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1276-7009","authenticated-orcid":false,"given":"Leonie G.","family":"Tigelaar","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center For Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-1028","authenticated-orcid":false,"given":"Johannes H. 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