{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:37:50Z","timestamp":1791229070678,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014607","name":"Royal Children's Hospital Foundation","doi-asserted-by":"publisher","award":["2019\u20101193"],"award-info":[{"award-number":["2019\u20101193"]}],"id":[{"id":"10.13039\/100014607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platinum\u2010based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin\u2010induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>We identified a large cohort of children with cancer treated with carboplatin and graded their audiograms using the SIOP Boston ototoxicity scale. Patients with inadequate audiological follow\u2010up, prior hearing loss, or exposure to cisplatin were excluded. Fisher's exact test, logistic regression, and ROC analyses were performed to investigate associations of demographic, treatment and exposure\u2010related risk factors with incidence of hearing loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 200 patients were included, all of whom had been treated with carboplatin. Only nine (4.5%) patients developed clinically significant hearing loss (SIOP Boston grade \u22652). Younger age at first exposure to carboplatin was the only significant predictor of hearing loss (OR = 0.7888,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0241). Age \u226428 months was significantly associated with hearing loss (OR 12.37,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0042). No other risk factors or exposures were statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinically significant carboplatin\u2010associated hearing loss was uncommon (incidence 4.5%). We show that young age is the single\u2010most important risk factor for hearing loss; of nine children who developed hearing loss, eight were aged \u226428 months. Children below this age have 12\u2010fold higher odds of developing hearing loss compared to those above this age (OR 12.37). These findings will allow physicians to provide more appropriate counselling to families regarding ototoxic risk and support intensified hearing surveillance in young children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70494","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:20:18Z","timestamp":1785136818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence and Severity of Carboplatin\u2010Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria"],"prefix":"10.1002","volume":"73","author":[{"given":"Aniket","family":"Chawla","sequence":"first","affiliation":[{"name":"Children's Cancer Centre, Royal Children's Hospital  Parkville Melbourne Australia"},{"name":"Murdoch Children's Research Institute  Parkville Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Carter","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre, Royal Children's Hospital  Parkville Melbourne Australia"},{"name":"Murdoch Children's Research Institute  Parkville Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Staffieri","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Parkville Melbourne Australia"},{"name":"Department of Ophthalmology Royal Children's Hospital  Parkville Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Dodgshun","sequence":"additional","affiliation":[{"name":"Children's Haematology\/Oncology Centre  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Eisenstat","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre, Royal Children's Hospital  Parkville Melbourne Australia"},{"name":"Murdoch Children's Research Institute  Parkville Melbourne Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre, Royal Children's Hospital  Parkville Melbourne Australia"},{"name":"Murdoch Children's Research Institute  Parkville Melbourne Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e3283650bda"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.5355"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25618"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.9744"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-010-1300-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442435"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.08.016"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00020-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcped.2023.100017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33848"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.12.PEDS11357"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22578"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2016.10.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.1110"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210646"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051266"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13235963"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21898"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26931"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.14238\/pi55.3.2015.121-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.2319"},{"issue":"1","key":"e_1_2_8_23_1","first-page":"41","article-title":"Audiometry Screening and Interpretation","volume":"87","author":"Walker J. 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