{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:34Z","timestamp":1787761054581,"version":"build-2784847793"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia. Four children with severe hemophilia A or moderate\u2010to\u2010severe hemophilia B underwent T2* MRI after persistent joint symptoms. One patient demonstrated shortened T2* relaxation (9 ms) with structural joint pathology, while three showed higher values (22\u201326 ms) without pathology. Despite low bleeding rates and joint scores, T2* MRI identified occult damage, supporting its potential for early, personalized intervention in pediatric hemophilia populations globally.<\/jats:p>","DOI":"10.1002\/1545-5017.70518","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:15:45Z","timestamp":1784902545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-5531","authenticated-orcid":false,"given":"Jessica","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Hematology and Oncology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Children's Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarique","family":"Hussain","sequence":"additional","affiliation":[{"name":"Children's Health  Dallas Texas USA"},{"name":"Department of Pediatrics, Division of Pediatric Cardiology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Radiology, Division of Pediatric Radiology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Dillenbeck","sequence":"additional","affiliation":[{"name":"Children's Health  Dallas Texas USA"},{"name":"Department of Radiology, Division of Pediatric Radiology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hammer","sequence":"additional","affiliation":[{"name":"Children's Health  Dallas Texas USA"},{"name":"Department of Radiology, Division of Pediatric Radiology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"von Drygalski","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-1254","authenticated-orcid":false,"given":"Guy","family":"Young","sequence":"additional","affiliation":[{"name":"Hemostasis and Thrombosis Center, Cancer and Blood Diseases Institute Children's Hospital Los Angeles University of Southern California Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-0415","authenticated-orcid":false,"given":"Ayesha","family":"Zia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology and Oncology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Children's Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","article-title":"Non\u2010Clotting Factor Therapies for Preventing Bleeds in People With Congenital Hemophilia A or B","volume":"2","author":"Olasupo O. 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