{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:39Z","timestamp":1787761059258,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA098543 U10CA180899 U10CA180886"],"award-info":[{"award-number":["U10CA098543 U10CA180899 U10CA180886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1CA097452"],"award-info":[{"award-number":["UM1CA097452"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189955"],"award-info":[{"award-number":["UG1CA189955"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["3UG1CA189960\u201011S1"],"award-info":[{"award-number":["3UG1CA189960\u201011S1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Despite 5\u2010year survival rates of over 90% among children and adolescents\/young adults (CAYAs) with classic Hodgkin lymphoma (cHL), 15%\u201320% relapse after frontline therapy. Prior analysis of frontline Children's Oncology Group (COG) clinical trials demonstrated that, despite similar rates of relapse, non\u2010Hispanic Black (NHB) and Hispanic (vs. non\u2010Hispanic White [NHW]) patients experienced higher post\u2010relapse mortality. It is unknown whether post\u2010relapse disparities persist when second\u2010line treatment is delivered in a cooperative group trial setting. We examined overall survival (OS) by race and ethnicity in CAYAs enrolled in COG trials for relapsed\/refractory (r\/r) cHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A pooled analysis of individual\u2010level data from CAYAs (\u2264 29 years) receiving therapy for r\/r cHL on COG clinical trials (2001\u20132016) was conducted. The Kaplan\u2013Meier method estimated 3\u2010year OS by racial and ethnic groups. Cox regression models examined associations of race and ethnicity and OS, adjusted for age, insurance, first versus \u22652 relapse, and time from initial diagnosis to relapse trial enrollment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 175 CAYAs treated on COG trials for r\/r cHL (5.7% Asian or Pacific Islander, 14.9% Hispanic, 14.3% NHB, 61.7% NHW, 3.4% other), at median follow\u2010up of 4.9 years, 3\u2010year OS was 82.1% (95% confidence interval [CI], 75.3%\u201387.1%) and did not differ by race and ethnicity (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.36). In multivariable analyses, shorter time from diagnosis to relapse trial enrollment (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01) and \u22652 relapses (vs. first,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) conferred worse OS, with no significant effect of race and ethnicity (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.43).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post\u2010relapse survival did not differ by race and ethnicity among CAYAs enrolled in COG trials for r\/r cHL, suggesting access to clinical trials may mitigate OS disparities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70522","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:23:48Z","timestamp":1784903028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival by Race and Ethnicity in Children and Adolescents\/Young Adults With Relapsed\/Refractory Hodgkin Lymphoma: A Pooled Analysis of Children's Oncology Group Trials"],"prefix":"10.1002","volume":"73","author":[{"given":"Mallorie B.","family":"Heneghan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology\/Oncology University of Utah\/Primary Children's Hospital  Salt Lake City Utah USA"},{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Renfro","sequence":"additional","affiliation":[{"name":"University of Southern California and Children's Oncology Group  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Statistics &amp; Data Center  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia M.","family":"Crisler","sequence":"additional","affiliation":[{"name":"Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Marcotte","sequence":"additional","affiliation":[{"name":"University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Trippett","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terzah","family":"Horton","sequence":"additional","affiliation":[{"name":"Texas Children's Cancer Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford S.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Keller","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Aflac Cancer and Blood Disorders Center\/Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Forlenza","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Children's Wisconsin Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Roswell Park Comprehensive Cancer Center University at Buffalo Jacobs School of Medicine and Biomedical Sciences  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Cole","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Robert Wood Johnson Medical School, Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Castellino","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Aflac 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