{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:42Z","timestamp":1787761062567,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["CSDG\u201022\u2010102\u201001\u2010CPSH"],"award-info":[{"award-number":["CSDG\u201022\u2010102\u201001\u2010CPSH"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer\u2010predisposing germline variants are increasingly identified and disclosed during pediatric oncology clinical care. To understand whether and how parents communicate about identified cancer predisposition syndromes (CPS) with their adolescent and young adult (AYA) children, this study qualitatively characterized the content and approach (e.g., timing) of parent\u2013AYA communication about AYAs\u2019 CPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>AYAs with a CPS identified during clinical cancer care and their parents independently completed semi\u2010structured interviews regarding their CPS\u2010related communication. Interviews were completed 1.0\u20133.99 years following genetic test result disclosure and coded using inductive content analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010one AYAs (age 13\u201320 years) and 24 parents (17 mothers, 6 fathers, 1 grandmother) completed interviews. Although most parents reported repeatedly communicating with their child, several AYAs did not recall these conversations and nearly half described a one\u2010time conversation. Parents described communicating to disclose genetic results, educate regarding cancer risk, attend to AYAs\u2019 emotions, and provide anticipatory guidance for future risk management. Parents whose AYA had a CPS conferring risk for adult\u2010onset cancers (e.g., colon cancer) expected to continue to remind their AYA about cancer surveillance well into adulthood. Parents and AYAs described their CPS\u2010related communication as \u201clight,\u201d prompted by the AYAs\u2019 medical appointments and questions, and impacted by parents\u2019 understanding of the CPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight areas for targeted genetic education and support. Parents may benefit from screening to ascertain their CPS understanding, education regarding AYAs\u2019 CPS\u2010related information and emotional support needs, and support for transitioning AYAs to independently manage CPS\u2010related health needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Trial Registration: ClinicalTrials.gov identifier: NCT04848142<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70530","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:30:46Z","timestamp":1784964646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Qualitative Analysis of Parent\u2013AYA Communication About Cancer Predisposition Diagnosed During Pediatric Cancer Care"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-9702","authenticated-orcid":false,"given":"Katianne M.","family":"Howard Sharp","sequence":"first","affiliation":[{"name":"Department of Psychology &amp; Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alise","family":"Blake","sequence":"additional","affiliation":[{"name":"Department of Oncology, Division of Cancer Predisposition St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Humphrey","sequence":"additional","affiliation":[{"name":"Department of Psychology &amp; Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Psychology University of Mississippi  Oxford Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-4701","authenticated-orcid":false,"given":"Jessica S.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Psychology &amp; Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Oncology, Division of Cancer Predisposition St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose B.","family":"McGee","sequence":"additional","affiliation":[{"name":"Department of Oncology, Division of Cancer Predisposition St. Jude Children's Research Hospital  Memphis Tennessee 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