{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:31:25Z","timestamp":1793287885904,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP210075,RP160771,CP230026"],"award-info":[{"award-number":["RP210075,RP160771,CP230026"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P20CA262733"],"award-info":[{"award-number":["P20CA262733"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U54CA302464"],"award-info":[{"award-number":["U54CA302464"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA272981"],"award-info":[{"award-number":["R01CA272981"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurotoxicity is a rare, often dose\u2010limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX\u2010related neurotoxicity susceptibility among Latino children undergoing therapy for pediatric acute lymphoblastic leukemia (ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>The study cohort was composed of 429 self\u2010identifying Latino children diagnosed with ALL (2005\u20132019) between the ages of 2 and 20 years treated at one of six US pediatric cancer treatment centers. MTX\u2010related neurotoxicity was defined as neurologic episodes (e.g., seizures, stroke\u2010like symptoms, altered mental status, and tremors) occurring within 21 days of intravenous (IV) and\/or intrathecal (IT) MTX that were documented by magnetic resonance imaging (MRI) abnormalities and\/or clinical symptoms. Among the 429 patients, we identified 46 (10.7%) Latino children with neurotoxicity. Admixture mapping was used to identify local genomic regions that are associated with the risk of MTX\u2010related neurotoxicity among Latino children with ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ultimately, this study identified 11 genomic regions carrying suggestive associations with MTX\u2010neurotoxicity risk among Latino children with ALL. Review of biological plausibility of the loci within these regions revealed associations with areas of the brain or downstream regulatory functions. Results from this study may guide future work to further interrogate these regions through fine\u2010mapping to identify genetic variants associated with increased risk of MTX\u2010related neurotoxicity among Latino children with ALL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70554","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:29:08Z","timestamp":1785752948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report"],"prefix":"10.1002","volume":"73","author":[{"given":"Rachel D.","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Epidemiology Human Genetics and Environmental Sciences University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya B.","family":"Shetty","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Population Science Department of Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Dan L Duncan Comprehensive Cancer Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth G.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-9860","authenticated-orcid":false,"given":"Melissa A.","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology and Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0947-104X","authenticated-orcid":false,"given":"M. Monica","family":"Gramatges","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology and Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Zobeck","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology and Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-9176","authenticated-orcid":false,"given":"Sandi","family":"Pruitt","sequence":"additional","affiliation":[{"name":"Department of Public Health Peter O'Donnell School of Public Health University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-0282","authenticated-orcid":false,"given":"Amy","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Public Health Peter O'Donnell School of Public Health University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Brooke","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7986-601X","authenticated-orcid":false,"given":"Ashley","family":"Chavana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology and Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Huynh","sequence":"additional","affiliation":[{"name":"Hyundai Cancer Institute Children's Hospital of Orange County  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Public Health Peter O'Donnell School of Public Health University of Texas Southwestern Medical Center  Dallas 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