{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:34:43Z","timestamp":1787758483137,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004785","name":"NordForsk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010733","name":"B\u00f8rnecancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005940","name":"Dansk Kr\u00e6ftforsknings Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005940","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Survivors of acute lymphoblastic leukemia (ALL) have reduced lean body mass compared with the general population. In healthy children, an association between lean body mass and kidney size has been reported, while this correlation in ALL survivors remains unexplored. Understanding this correlation is essential when evaluating kidney size during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>The study cohort included 240 ALL survivors, diagnosed between ages 1 and 45\u00a0years in Denmark between 2008 and 2018, treated according to the NOPHO ALL2008 protocol, and having survived \u22651\u00a0year post\u2010treatment. A control group of 278 individuals from the general population, matched by sex and age, was included. Renal ultrasound and dual\u2010energy x\u2010ray absorptiometry scans were performed between 2019 and 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age at study participation was 13\u00a0years (range: 5\u201347) among survivors and 14\u00a0years (range: 5\u201353) among controls. Both female and male survivors had lower lean body mass than controls (females: median 30.3\u00a0kg [range: 12.6\u201355.6] vs. 37.8\u00a0kg [range: 15.0\u201364.2],\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.001; males: median 39.3\u00a0kg [range: 13.8\u201374.5] vs. 45.9\u00a0kg [range: 15.3\u201381.2],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.025). Female survivors had smaller total kidney volume than female controls (median 191.2\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      [range: 90.7\u2013341.0] vs. 216.1\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      [range: 94.4\u2013424.5],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003), while no significant difference was observed in males. Total kidney volume strongly correlated with lean body mass in both survivors and controls, explaining 73% and 65% of the variance in total kidney volume, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study underscores the importance of incorporating body composition measurements when evaluating kidney size in ALL survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70574","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:38:16Z","timestamp":1785242296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Kidney Size and Lean Body Mass in Survivors of Childhood and Young Adult Acute Lymphoblastic Leukemia"],"prefix":"10.1002","volume":"73","author":[{"given":"Elina Eriksson","family":"Wikberg","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Faculty of Medicine Lund University  Lund Sweden"},{"name":"Childhood Cancer Center Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Maria","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-9660","authenticated-orcid":false,"given":"Cornelis Jan","family":"Pronk","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Medicine Lund University  Lund Sweden"},{"name":"Childhood Cancer Center Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte Klug","family":"Albertsen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Bjurberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"H\u00f8rlyck","sequence":"additional","affiliation":[{"name":"Department of Radiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine\u2010Lise","family":"Lambine","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Tiedemann","family":"Skipper","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Tuckuviene","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder Skov","family":"Wehner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology H.C. Andersen Children's Hospital Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-4993","authenticated-orcid":false,"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Leth","family":"Frandsen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv","family":"Andres\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-8148","authenticated-orcid":false,"given":"Anna S\u00e4llfors","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Medicine Lund University  Lund Sweden"},{"name":"Childhood Cancer Center Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00637-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10768.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw557"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31610-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35148"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaa025"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6794"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29468"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30696"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117150"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112754"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.05.029"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-05402-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1214243"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670100568"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31736"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-014-0415-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31191"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045543"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.265"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29628"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-020-04164-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-05303-5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-022-05667-2"}],"container-title":["Pediatric Blood &amp; 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