{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:31:24Z","timestamp":1793287884589,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although significant progress has been made in childhood leukemia survival, healthcare providers, and caregivers often face challenges in explaining this disease to patients. Disease\u2010targeted storybooks have been proposed as a tool to facilitate the understanding of diagnoses and treatment. However, to date, no study has examined their effects on the anxiety of children with leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the effect of the disease\u2010targeted storybook in improving children's perceived disease\u2010 and treatment\u2010related anxiety and in educating patients about the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010arm pre\u2010post study was conducted among patients aged 4\u20137 years with acute childhood leukemia in Thailand. A disease\u2010targeted storybook was read to the participant, first by the researcher and then by their caregivers. This book provided information about illness and treatment while providing space for emotional expression. Disease\u2010 and treatment\u2010related anxieties were measured using a visual analogue scale at baseline, immediately after reading, and 2 weeks later. Knowledge was assessed using a 10\u2010item questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients participated in the study. Disease\u2010related perceived anxiety decreased from 4.4 (95% confidence interval [CI]\u20142.91\u20135.89) to 2.9 (95%CI\u20141.41\u20134.39) immediately (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.066) and remained at 2.35 (95%CI\u20140.86\u20133.84) 2 weeks later (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012). Treatment\u2010related perceived anxiety declined from 7.9 (95%CI\u20146.56\u20139.24) to 6.15 (95%CI\u20144.81\u20137.49) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034) and to 4.1 (95%CI\u20142.76\u20135.44) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Knowledge improved significantly. Most children and their caregivers reported satisfaction with the storybook.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A disease\u2010targeted storybook can serve as an adjunctive clinical tool to reduce anxiety and improve disease\u2010related knowledge among pediatric patients with acute leukemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70580","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:16:27Z","timestamp":1784970987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Implementation of a Disease\u2010Targeted Storybook as a Clinical Tool for Children With Acute Leukemia"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8184-328X","authenticated-orcid":false,"given":"Nutvipha","family":"Ummartyotin","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-7471","authenticated-orcid":false,"given":"Usanarat","family":"Anurathapan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawiwan","family":"Roongpraiwan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Potchanee","family":"Dandamrongrak","sequence":"additional","affiliation":[{"name":"Department of Nursing Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn","family":"Nakhonchai","sequence":"additional","affiliation":[{"name":"Department of Nursing Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawin","family":"Numthavaj","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1256-7843","authenticated-orcid":false,"given":"Vilawan","family":"Chirdkiatgumchai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"An Interactive Website for NCCR Cancer Statistics","author":"NCCR*Explorer","year":"2025"},{"key":"e_1_2_11_3_1","unstructured":"PPTE Board PDQ Childhood Acute Lymphoblastic Leukemia Treatment(National Cancer Institute 2025) https:\/\/www.cancer.gov\/types\/leukemia\/hp\/child\u2010all\u2010treatment\u2010pdq."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4236\/psych.2022.133021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2012.07.010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/PRBM.S488905"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_238181"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25675"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"208","article-title":"Pilot Randomized Trial of Active Music Engagement Intervention Parent Delivery for Young Children With Cancer","volume":"42","author":"Robb S. 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